Agonist and antagonist benzodiazepine receptor interaction in vitro.
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The affinities, potencies and efficacies of some benzodiazepine-receptor agonists, antagonists and inverse-agonists at rat hippocampal GABAA-receptors[11C]flumazenil binding is increased in a dose-dependent manner with tiagabine-induced elevations in GABA levelsPatch-clamp study of gamma-aminobutyric acid receptor Cl- channels in cultured astrocytes.Differential depression of neuronal network activity by midazolam and its main metabolite 1-hydroxymidazolam in cultured neocortical slices.Lack of effect of nitrendipine on the pharmacokinetics and pharmacodynamics of midazolam during steady stateThe interaction of substituted benzamides with brain benzodiazepine binding sites in vitro.Increase in the Bmax of gamma-aminobutyric acid-A recognition sites in brain regions of mice receiving diazepam.Tiagabine increases [11C]flumazenil binding in cortical brain regions in healthy control subjectsDemonstration of benzodiazepine-like molecules in the mammalian brain with a monoclonal antibody to benzodiazepines.beta-Carbolines enhance shock-induced suppression of drinking in rats.Effects of naloxone and flumazenil on antinociceptive action of acetaminophen in rats.Understanding the GABAA receptor: a chemically gated ion channel.The benzodiazepine receptor.[Current hypotheses of the central mechanism of action of benzodiazepine tranquilizers]Postnatal development of proteins associated with different benzodiazepine receptors.Histamine H3-receptor agonists and imidazole-based H3-receptor antagonists can be thermodynamically discriminated.Effect of flumazenil on disturbance of equilibrium function induced by midazolam.Inhibition of [3H]diazepam and [3H]3-carboethoxy-beta-carboline binding by irazepine: evidence for multiple "domains" of the benzodiazepine receptor.Characterization of [3H]-imidazenil binding to rat brain membranesPharmacokinetics of the new benzodiazepine antagonist Ro 15-1788 in man following intravenous and oral administration.Thermodynamic analysis of agonist and antagonist binding to the chicken brain melatonin receptor.Antagonism of the central effects of 3-methylclonazepam.The use of flumazenil (Anexate, Ro 15-1788) in the management of drug overdose.Receptor binding at two different temperatures to discriminate agonist and antagonist behaviour of adenosine A1 receptor ligands in rat brain.Competitive Antagonism of Anesthetic Action at the γ-Aminobutyric Acid Type A Receptor by a Novel Etomidate Analog with Low Intrinsic Efficacy.Partial reversal of the cerebral effects of isoflurane in the dog by the benzodiazepine antagonist flumazenil.Evidence that background GABAergic tone and possible ligand release may alter the action of the 'neutral' benzodiazepine-receptor antagonist, Ro 15-1788, in hypothalamic self-stimulation.In vivo [11C]flumazenil-PET correlates with ex vivo [3H]flumazenil autoradiography in hippocampal sclerosis.Regional distribution and kinetics of three sites on the GABAA receptor: lack of effect of portacaval shunting.Influence of agonist induced internalization on [3H]Ro15-4513 binding-an application to imaging fluctuations in endogenous GABA with positron emission tomography.Photoaffinity labelling of the benzodiazepine receptor compromises the recognition site but not its effector mechanism.The visualization of neuronal benzodiazepine receptors in the brain by autoradiography and immunohistochemistry.Binding of [3H]DMCM, a convulsive benzodiazepine ligand, to rat brain membranes: preliminary studies.Comparison of the kinetics of [3H]diazepam and [3H]flunitrazepam binding to cortical synaptosomal membranes.Temperature dependence of [3H]Ro 15-1788 binding to benzodiazepine receptors in human postmortem brain homogenates.Pharmacodynamic interaction between midazolam and a specific benzodiazepine antagonist in humans.The biological basis of benzodiazepine actions.Diazepam biphasically modulates [3H]TBOB binding to the convulsant site of the GABAA receptor complex.Comparative thermodynamics of benzodiazepine receptor ligand interactions in rat neuronal membranes.Poster Communications
P2860
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P2860
Agonist and antagonist benzodiazepine receptor interaction in vitro.
description
1981 nî lūn-bûn
@nan
1981年の論文
@ja
1981年学术文章
@wuu
1981年学术文章
@zh
1981年学术文章
@zh-cn
1981年学术文章
@zh-hans
1981年学术文章
@zh-my
1981年学术文章
@zh-sg
1981年學術文章
@yue
1981年學術文章
@zh-hant
name
Agonist and antagonist benzodiazepine receptor interaction in vitro.
@en
Agonist and antagonist benzodiazepine receptor interaction in vitro.
@nl
type
label
Agonist and antagonist benzodiazepine receptor interaction in vitro.
@en
Agonist and antagonist benzodiazepine receptor interaction in vitro.
@nl
prefLabel
Agonist and antagonist benzodiazepine receptor interaction in vitro.
@en
Agonist and antagonist benzodiazepine receptor interaction in vitro.
@nl
P356
P1433
P1476
Agonist and antagonist benzodiazepine receptor interaction in vitro.
@en
P2093
P2888
P304
P356
10.1038/294763A0
P407
P577
1981-12-01T00:00:00Z
P6179
1039773988