Disruption of the mouse Necdin gene results in hypothalamic and behavioral alterations reminiscent of the human Prader-Willi syndrome.
about
Deletion of the MBII-85 snoRNA gene cluster in mice results in postnatal growth retardationNecdin-related MAGE proteins differentially interact with the E2F1 transcription factor and the p75 neurotrophin receptorMAGE-A1 interacts with adaptor SKIP and the deacetylase HDAC1 to repress transcriptionSeparate necdin domains bind ARNT2 and HIF1alpha and repress transcriptionA necdin/MAGE-like gene in the chromosome 15 autism susceptibility region: expression, imprinting, and mapping of the human and mouse orthologuesThe Prader-Willi syndrome murine imprinting center is not involved in the spatio-temporal transcriptional regulation of the Necdin geneFrom Autism to Eating Disorders and More: The Role of Oxytocin in Neuropsychiatric DisordersThe neurobiology of the Prader-Willi phenotype of fragile X syndromeThe p75 neurotrophin receptor interacts with multiple MAGE proteinsA RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1Cancer/testis antigens: an expanding family of targets for cancer immunotherapyEctopic expression of necdin induces differentiation of mouse neuroblastoma cellsNecdin interacts with the Msx2 homeodomain protein via MAGE-D1 to promote myogenic differentiation of C2C12 cellsDevelopmental abnormalities of neuronal structure and function in prenatal mice lacking the prader-willi syndrome gene necdinEpigenetic functions of smchd1 repress gene clusters on the inactive X chromosome and on autosomesNSCL-1 and NSCL-2 synergistically determine the fate of GnRH-1 neurons and control necdin gene expressionLoss of magel2, a candidate gene for features of Prader-Willi syndrome, impairs reproductive function in mice.Learning by observation and learning by doing in Prader-Willi syndrome.Stochastic loss of silencing of the imprinted Ndn/NDN allele, in a mouse model and humans with prader-willi syndrome, has functional consequences.Sensory defects in Necdin deficient mice result from a loss of sensory neurons correlated within an increase of developmental programmed cell death.Discovery of imprinted transcripts in the mouse transcriptome using large-scale expression profilingImprinted Nesp55 influences behavioral reactivity to novel environmentsNecdin promotes ubiquitin-dependent degradation of PIAS1 SUMO E3 ligasep53 regulates hematopoietic stem cell quiescence.Mice with altered serotonin 2C receptor RNA editing display characteristics of Prader-Willi syndrome.Necdin protects embryonic motoneurons from programmed cell death.Imprinted genes and mental dysfunction.Embryonic gonadotropin-releasing hormone signaling is necessary for maturation of the male reproductive axis.Necdin controls proliferation of white adipocyte progenitor cells.An unexpected function of the Prader-Willi syndrome imprinting center in maternal imprinting in miceA paternal deletion of MKRN3, MAGEL2 and NDN does not result in Prader-Willi syndromeThe developmental program of the hypothalamus and its disorders.The role of genomic imprinting in biology and disease: an expanding view.Gonadotropin-releasing hormone (GnRH) neuron migration: initiation, maintenance and cessation as critical steps to ensure normal reproductive functionThe MAGE proteins: emerging roles in cell cycle progression, apoptosis, and neurogenetic disease.The metabolic phenotype of Prader-Willi syndrome (PWS) in childhood: heightened insulin sensitivity relative to body mass index.Non-coding RNAs in imprinted gene clusters.Sleep and breathing in Prader-Willi syndrome.Oxytocin and vasopressin systems in genetic syndromes and neurodevelopmental disordersPathology from evolutionary conflict, with a theory of X chromosome versus autosome conflict over sexually antagonistic traits.
P2860
Q21092489-E504ACA0-0399-4F94-BEF6-30FE84CB6270Q24298935-B51668AA-9377-49CC-8BA3-95BCB385FAACQ24301553-1EAAC5A1-8E58-463C-9D57-3D6480185E62Q24674557-2BD32CB7-F2D4-4070-854B-8E3412E0C3D9Q24797302-D906F388-9D8C-4572-9C95-3C7882819AA5Q24808766-30470C72-F7EB-4265-B6C9-643E9D85DC16Q26770469-A49AA899-BEEA-4C92-8D16-6FFB9B440D2BQ28078294-F30DCD60-0F93-4381-9CAD-7CEEC05A6B01Q28213040-D545ACD2-7347-46C3-B977-6AE130744EE3Q28215071-D9DB066F-F1F9-4D63-84B2-35C7FB636831Q28215652-FD216F54-2752-4D46-9750-30CD22E44390Q28219184-34C176C0-1273-4620-9165-EDF8682B9EA7Q28505040-144CC05C-01C1-4680-AB31-E8926C6D6653Q28585818-5C26B43E-69B4-4AF7-8070-E73670E5001DQ28590537-03876C40-6AA2-4B4C-8B76-16A264AB9E6AQ28591595-DF1B061C-05DB-4E3D-BC33-A1C1B29B4FD9Q30440358-03CBADE4-1FBA-403C-B464-F26A100F1F8DQ30643463-35F73F1D-4271-4379-B5E4-237A14D73BFAQ31138426-3AA915BC-1769-40A0-A648-03961BAEE18FQ33264123-CADF439B-BEF7-4A43-A4C5-F39F2120C70BQ33678359-C42A7C16-9172-4700-8961-5FE0287E7708Q33724476-F3EDF9C6-2F0E-41FD-859D-7E298A76BE5BQ33727985-57E0021A-AFD0-4C09-A0F6-C374EB589DC0Q33732098-302C7058-D2B0-4A86-8690-75B9D3D91381Q34006076-2E537D43-94F2-408C-BE51-D1235514564BQ34017758-BA829031-A075-4BD9-AEE5-20FB9BCBE1F2Q34093571-5AD3F198-78C4-46E6-8086-9F8ACF3395BDQ34136448-8E874228-52BD-466C-A2AB-F1B8448250F4Q34146581-8F2DBC9F-3B03-44AE-8F7F-F49FE3A89D45Q34230048-58C089B6-3BEE-41F4-A76C-B335D2DD0646Q34326210-E8AD5976-5C8E-4766-B025-68260BEEDDE8Q34421524-142443D5-1E67-4AAD-B1A7-A9F32C32F8EBQ34426232-8735630D-B8D9-4E26-B2A8-3525C515C02DQ34433460-B4A1DC52-7DC5-43C7-A2CA-AAF43726FBD6Q34561533-9338E541-4F5C-4BD4-9DB7-7C79DBA44B8FQ34571772-33730923-9A74-40DA-8A39-C4FF62850349Q34749691-154D7F81-5E77-4795-A06B-BA2C2A635DF1Q34804102-D850129C-6F1F-4218-AFB1-2EB27CB9AA37Q35009426-CE4567A5-BB94-41C1-A992-97F749A88674Q35092394-6CD3488D-7FD4-4B5D-A88D-7357C5C00C45
P2860
Disruption of the mouse Necdin gene results in hypothalamic and behavioral alterations reminiscent of the human Prader-Willi syndrome.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
2000年學術文章
@zh-hant
name
Disruption of the mouse Necdin ...... e human Prader-Willi syndrome.
@en
Disruption of the mouse Necdin ...... e human Prader-Willi syndrome.
@nl
type
label
Disruption of the mouse Necdin ...... e human Prader-Willi syndrome.
@en
Disruption of the mouse Necdin ...... e human Prader-Willi syndrome.
@nl
prefLabel
Disruption of the mouse Necdin ...... e human Prader-Willi syndrome.
@en
Disruption of the mouse Necdin ...... e human Prader-Willi syndrome.
@nl
P2093
P50
P356
P1476
Disruption of the mouse Necdin ...... he human Prader-Willi syndrome
@en
P2093
P304
P356
10.1093/HMG/9.20.3101
P577
2000-12-01T00:00:00Z