Otoferlin is a multivalent calcium-sensitive scaffold linking SNAREs and calcium channels.

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Emerging Functional Differences between the Synaptotagmin and Ferlin Calcium Sensor Families.Otoferlin acts as a Ca2+ sensor for vesicle fusion and vesicle pool replenishment at auditory hair cell ribbon synapses.GC-B Deficient Mice With Axon Bifurcation Loss Exhibit Compromised Auditory Processing

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P2860

Otoferlin is a multivalent calcium-sensitive scaffold linking SNAREs and calcium channels.

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http://www.wikidata.org/entity/Q49839459

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2017 nî lūn-bûn

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2017年の論文

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2017年学术文章

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Otoferlin is a multivalent cal ...... g SNAREs and calcium channels.

@en

Otoferlin is a multivalent cal ...... g SNAREs and calcium channels.

@nl

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Item

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Otoferlin is a multivalent cal ...... g SNAREs and calcium channels.

@en

Otoferlin is a multivalent cal ...... g SNAREs and calcium channels.

@nl

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Otoferlin is a multivalent cal ...... g SNAREs and calcium channels.

@en

Otoferlin is a multivalent cal ...... g SNAREs and calcium channels.

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P1476

Otoferlin is a multivalent cal ...... g SNAREs and calcium channels.

@en

P2093

Murugesh Padmanarayana

http://www.w3.org/2001/XMLSchema#string

Nicole Hams

http://www.w3.org/2001/XMLSchema#string

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A mutation in OTOF, encoding otoferlin, a FER-1-like protein, causes DFNB9, a nonsyndromic form of deafness

Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse

Hearing requires otoferlin-dependent efficient replenishment of synaptic vesicles in hair cells

Otoferlin deficiency in zebrafish results in defects in balance and hearing: rescue of the balance and hearing phenotype with full-length and truncated forms of mouse otoferlin.

Probing the functional equivalence of otoferlin and synaptotagmin 1 in exocytosis.

Single-molecule pull-down for studying protein interactions.

How does synaptotagmin trigger neurotransmitter release?

Single-molecule high-resolution imaging with photobleaching

Characterization of the lipid binding properties of Otoferlin reveals specific interactions between PI(4,5)P2 and the C2C and C2F domains.

Otoferlin is a calcium sensor that directly regulates SNARE-mediated membrane fusion.

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8023-8028

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scholarly article

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10.1073/PNAS.1703240114

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English

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http://www.w3.org/2001/XMLSchema#string

P478

114

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P50

Weihong Qiu

Colin P Johnson

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2017-07-10T00:00:00Z

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P698

28696301

http://www.w3.org/2001/XMLSchema#string

P932

5544299

http://www.w3.org/2001/XMLSchema#string

Otoferlin is a multivalent calcium-sensitive scaffold linking SNAREs and calcium channels.

about

P2860

P2860

Otoferlin is a multivalent calcium-sensitive scaffold linking SNAREs and calcium channels.

description

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type

label

prefLabel

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698

P932