Discovery of Tetralones as Potent and Selective Inhibitors of Acyl-CoA:Diacylglycerol Acyltransferase 1.

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Discovery of Tetralones as Potent and Selective Inhibitors of Acyl-CoA:Diacylglycerol Acyltransferase 1.

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2018 nî lūn-bûn

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2018年の論文

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2018年学术文章

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2018年学术文章

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2018年学术文章

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2018年学术文章

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2018年学术文章

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2018年学术文章

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2018年學術文章

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2018年學術文章

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name

Discovery of Tetralones as Pot ...... cylglycerol Acyltransferase 1.

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Discovery of Tetralones as Pot ...... cylglycerol Acyltransferase 1.

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Item

label

Discovery of Tetralones as Pot ...... cylglycerol Acyltransferase 1.

@en

Discovery of Tetralones as Pot ...... cylglycerol Acyltransferase 1.

@nl

prefLabel

Discovery of Tetralones as Pot ...... cylglycerol Acyltransferase 1.

@en

Discovery of Tetralones as Pot ...... cylglycerol Acyltransferase 1.

@nl

P1476

Discovery of Tetralones as Pot ...... cylglycerol Acyltransferase 1.

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P2093

Hemant V Joshi

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Jennifer L Ariazi

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Mui Cheung

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Raghuram S Tangirala

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Sanjay Kumar

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Sridhar R Bethi

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Vijaya G Tirunagaru

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P2860

Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat.

Inhibition of triglyceride synthesis as a treatment strategy for obesity: lessons from DGAT1-deficient mice.

Fatty acids, triglycerides, and glucose metabolism: recent insights from knockout mice.

Specific role for acyl CoA:Diacylglycerol acyltransferase 1 (Dgat1) in hepatic steatosis due to exogenous fatty acids.

Pharmacological inhibition of diacylglycerol acyltransferase 1 reduces body weight gain, hyperlipidemia, and hepatic steatosis in db/db mice.

Role of in silico genotoxicity tools in the regulatory assessment of pharmaceutical impurities.

Current status of the research and development of diacylglycerol O-acyltransferase 1 (DGAT1) inhibitors.

Therapeutic strategies for metabolic diseases: Small-molecule diacylglycerol acyltransferase (DGAT) inhibitors.

Acyltransferase inhibitors: a patent review (2010-present).

Discovery of PF-04620110, a Potent, Selective, and Orally Bioavailable Inhibitor of DGAT-1.

P304

103-108

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P31

scholarly article

P356

10.1021/ACSMEDCHEMLETT.7B00450

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P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

P577

2018-01-16T00:00:00Z

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P698

29456796

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P932

5807866

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