Heterogeneity of Phosphatidylinositol-3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin Activation in Cancer: Is PI3K Isoform Specificity Important?

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Signal-Targeted Therapies and Resistance Mechanisms in Pancreatic Cancer: Future Developments Reside in Proteomics.

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Heterogeneity of Phosphatidylinositol-3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin Activation in Cancer: Is PI3K Isoform Specificity Important?

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2017 nî lūn-bûn

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2017年の論文

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2017年学术文章

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Heterogeneity of Phosphatidyli ...... Isoform Specificity Important?

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Heterogeneity of Phosphatidylinositol-3-Kinase

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Heterogeneity of Phosphatidyli ...... Isoform Specificity Important?

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Heterogeneity of Phosphatidylinositol-3-Kinase

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Heterogeneity of Phosphatidyli ...... Isoform Specificity Important?

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Heterogeneity of Phosphatidylinositol-3-Kinase

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Heterogeneity of Phosphatidyli ...... Isoform Specificity Important?

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Célia Cintas

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The p110α and p110β isoforms of PI3K play divergent roles in mammary gland development and tumorigenesis.

Characterization of the novel and specific PI3Kα inhibitor NVP-BYL719 and development of the patient stratification strategy for clinical trials.

Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor.

Systematic identification of genomic markers of drug sensitivity in cancer cells

The emerging mechanisms of isoform-specific PI3K signalling

PI3Kδ inhibition by idelalisib in patients with relapsed indolent lymphoma.

Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancer.

PIK3CA mutations in androgen receptor-positive triple negative breast cancer confer sensitivity to the combination of PI3K and androgen receptor inhibitors.

Pancreatic cell plasticity and cancer initiation induced by oncogenic Kras is completely dependent on wild-type PI 3-kinase p110α

PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting.

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10.3389/FONC.2017.00330

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Julie Guillermet-Guibert

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Heterogeneity of Phosphatidylinositol-3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin Activation in Cancer: Is PI3K Isoform Specificity Important?

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P2860

P2860

Heterogeneity of Phosphatidylinositol-3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin Activation in Cancer: Is PI3K Isoform Specificity Important?

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P1433

P1476

P2093

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P356

P478

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P698

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P2093

P2860

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P31

P356

P478

P50

P577

P698

P932