about
The PDE1/5 Inhibitor SCH-51866 Does Not Modify Disease Progression in the R6/2 Mouse Model of Huntington's DiseaseHDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegenerationEfficacy of selective PDE4D negative allosteric modulators in the object retrieval task in female cynomolgus monkeys (Macaca fascicularis)Design, synthesis, and biological evaluation of potent and selective class IIa histone deacetylase (HDAC) inhibitors as a potential therapy for Huntington's diseaseStriatal pre- and postsynaptic profile of adenosine A(2A) receptor antagonistsOral administration of the pimelic diphenylamide HDAC inhibitor HDACi 4b is unsuitable for chronic inhibition of HDAC activity in the CNS in vivoHDAC4 does not act as a protein deacetylase in the postnatal murine brain in vivoExpansion of calcium microdomains regulates fast exocytosis at a ribbon synapseCharacterization of neurophysiological and behavioral changes, MRI brain volumetry and 1H MRS in zQ175 knock-in mouse model of Huntington's disease.Unravelling and Exploiting Astrocyte Dysfunction in Huntington's Disease.Evidence for an enhancement of excitatory transmission in adult CNS by Wnt signaling pathway modulation.Somatostatin receptor desensitization in NG108-15 cells. A consequence of receptor sequestration.Phosphorylation and local presynaptic protein synthesis in calcium- and calcineurin-dependent induction of crayfish long-term facilitation.Real-time measurement of exocytosis and endocytosis using interference of light.Calcium influx through HCN channels does not contribute to cAMP-enhanced transmission.The novel KMO inhibitor CHDI-340246 leads to a restoration of electrophysiological alterations in mouse models of Huntington's disease.Phosphodiesterase 10A Inhibition Improves Cortico-Basal Ganglia Function in Huntington's Disease Models.
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description
researcher
@en
wetenschapper
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հետազոտող
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name
Vahri Beaumont
@ast
Vahri Beaumont
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Vahri Beaumont
@es
Vahri Beaumont
@nl
Vahri Beaumont
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type
label
Vahri Beaumont
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Vahri Beaumont
@en
Vahri Beaumont
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Vahri Beaumont
@nl
Vahri Beaumont
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prefLabel
Vahri Beaumont
@ast
Vahri Beaumont
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Vahri Beaumont
@es
Vahri Beaumont
@nl
Vahri Beaumont
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P106
P31
P496
0000-0002-6488-2175