PIAS1;2-1 SUMOylate HIC1 with SUMO1 - Wikidata - wikimedia - TriplyDB

PIAS1;2-1 SUMOylate HIC1 with SUMO1

PIAS1;2-1 SUMOylate HIC1 with SUMO1

http://www.wikidata.org/entity/Q50296407

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SUMOylation of transcription factors

P527

Q45317691-99928769-06C0-40C1-8671-65BB1E843CBF

P527

PIAS1;2-1 SUMOylate HIC1 with SUMO1

http://www.wikidata.org/entity/Q50296407

description

An instance of the biological ...... IC1 with SUMO1 in Homo sapiens

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biologisch proces

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name

PIAS1;2-1 SUMOylate HIC1 with SUMO1

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type

label

PIAS1;2-1 SUMOylate HIC1 with SUMO1

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prefLabel

PIAS1;2-1 SUMOylate HIC1 with SUMO1

@en

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An acetylation/deacetylation-SUMOylation switch through a phylogenetically conserved psiKXEP motif in the tumor suppressor HIC1 regulates transcriptional repression activity

HIC1 (hypermethylated in cancer 1) SUMOylation is dispensable for DNA repair but is essential for the apoptotic DNA damage response (DDR) to irreparable DNA double-strand breaks (DSBs).

Differential regulation of HIC1 target genes by CtBP and NuRD, via an acetylation/SUMOylation switch, in quiescent versus proliferating cells.

DNA double-strand breaks lead to activation of hypermethylated in cancer 1 (HIC1) by SUMOylation to regulate DNA repair.

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reactome:R-HSA-4090281

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biological process

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SUMOylation of transcription factors

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R-HSA-4090281

http://www.w3.org/2001/XMLSchema#string

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HIC ZBTB transcriptional repressor 1

Ubiquitin conjugating enzyme E2 I

SUMO1:C93-UBE2I

P703