TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11 - Wikidata - wikimedia - TriplyDB

TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11

TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11

http://www.wikidata.org/entity/Q50296613

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E3 ubiquitin ligases ubiquitinate target proteins

P527

Q45317708-CEB03548-2892-46C3-9881-36F2D71954B2

P527

TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11

http://www.wikidata.org/entity/Q50296613

description

An instance of the biological ...... galovirus US11 in Homo sapiens

@en

biologisch proces

@nl

name

TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11

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type

label

TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11

@en

prefLabel

TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11

@en

P2860

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P2888

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P31

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P361

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P3937

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P527

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P703

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P2860

A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation

A membrane protein required for dislocation of misfolded proteins from the ER

A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol

Identifying the ERAD ubiquitin E3 ligases for viral and cellular targeting of MHC class I

The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol.

The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol

TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I.

P2888

reactome:R-HSA-8943080

P31

biological process

P361

E3 ubiquitin ligases ubiquitinate target proteins

P3937

R-HSA-8943080

http://www.w3.org/2001/XMLSchema#string

P527

Ubiquitin conjugating enzyme E2 J2

US11:HLA:TMEM129:DERL1:VIMP:VCP:Ub:UBE2J2

K48polyUb-HLA A-2;A-3;B-60

TMEM129:DERL1:VIMP:VCP:UBE2J2

P703