Ring opening of 4',5'-epoxynucleosides: a novel stereoselective entry to 4'-C-branched nucleosides.
about
From the chemistry of epoxy-sugar nucleosides to the discovery of anti-HIV agent 4'-ethynylstavudine-FestinavirEffect of conformational rigidity on the stereoselectivity of nucleophilic additions to five-membered ring bicyclic oxocarbenium ion intermediatesA review of methods to synthesise 4'-substituted nucleosides.Synthesis and properties of novel 2'-C,4'-C-ethyleneoxy-bridged 2'-deoxyribonucleic acids with exocyclic methylene groups.First synthesis and anti-HIV evaluation of 4'-methyl-cyclopentanyl 9-deazaadenosine.A new approach to the synthesis of 4'-carbon-substituted nucleosides: development of a highly active anti-HIV agent 2', 3'-didehydro-3'-deoxy-4'-ethynylthymidine.4'-Ethynylstavudine (4'-Ed4T) has potent anti-HIV-1 activity with reduced toxicity and shows a unique activity profile against drug-resistant mutants.Design, efficient synthesis, and anti-HIV activity of 4'-C-cyano- and 4'-C-ethynyl-2'-deoxy purine nucleosides.Synthesis and anti-HIV activity of 4'-cyano-2',3'-didehydro-3'-deoxythymidine.Synthesis of (+/-)-4'-ethynyl and 4'-cyano carbocyclic analogues of stavudine (d4T).An alternative synthetic method for 4'-C-ethynylstavudine by means of nucleophilic substitution of 4'-benzoyloxythymine nucleoside.Synthetic use of epoxy-sugar nucleosides.
P2860
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P2860
Ring opening of 4',5'-epoxynucleosides: a novel stereoselective entry to 4'-C-branched nucleosides.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
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2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
Ring opening of 4',5'-epoxynuc ...... to 4'-C-branched nucleosides.
@en
Ring opening of 4',5'-epoxynuc ...... to 4'-C-branched nucleosides.
@nl
type
label
Ring opening of 4',5'-epoxynuc ...... to 4'-C-branched nucleosides.
@en
Ring opening of 4',5'-epoxynuc ...... to 4'-C-branched nucleosides.
@nl
prefLabel
Ring opening of 4',5'-epoxynuc ...... to 4'-C-branched nucleosides.
@en
Ring opening of 4',5'-epoxynuc ...... to 4'-C-branched nucleosides.
@nl
P2093
P356
P1433
P1476
Ring opening of 4',5'-epoxynuc ...... to 4'-C-branched nucleosides.
@en
P2093
Hiromichi Tanaka
Kazuhiro Haraguchi
Shingo Takeda
P304
P356
10.1021/OL020259H
P407
P577
2003-05-01T00:00:00Z