CWC22 connects pre-mRNA splicing and exon junction complex assembly.
about
The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexusTwo mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decayA noncoding expansion in EIF4A3 causes Richieri-Costa-Pereira syndrome, a craniofacial disorder associated with limb defectsCrystal structure of the human eIF4AIII-CWC22 complex shows how a DEAD-box protein is inhibited by a MIF4G domainStructural and functional analysis of the three MIF4G domains of nonsense-mediated decay factor UPF2Cryo-EM structure of the spliceosome immediately after branchingThe EJC binding and dissociating activity of PYM is regulated in DrosophilaA multi-megabase copy number gain causes maternal transmission ratio distortion on mouse chromosome 2A post-translational regulatory switch on UPF1 controls targeted mRNA degradationThe exon junction complex controls transposable element activity by ensuring faithful splicing of the piwi transcript.The interaction of cytoplasmic poly(A)-binding protein with eukaryotic initiation factor 4G suppresses nonsense-mediated mRNA decay.Transcriptome-wide modulation of splicing by the exon junction complex.CWC22-dependent pre-mRNA splicing and eIF4A3 binding enables global deposition of exon junction complexes.Divergence patterns of genic copy number variation in natural populations of the house mouse (Mus musculus domesticus) reveal three conserved genes with major population-specific expansionsIntranuclear binding in space and time of exon junction complex and NXF1 to premRNPs/mRNPs in vivo.Male sex in houseflies is determined by Mdmd, a paralog of the generic splice factor gene CWC22.Recent transcriptome-wide mapping of UPF1 binding sites reveals evidence for its recruitment to mRNA before translation.Human spliceosomal protein CWC22 plays a role in coupling splicing to exon junction complex deposition and nonsense-mediated decay.Calpain-6 confers atherogenicity to macrophages by dysregulating pre-mRNA splicingExon junction complex proteins bind nascent transcripts independently of pre-mRNA splicing in Drosophila melanogaster.Endogenous U2·U5·U6 snRNA complexes in S. pombe are intron lariat spliceosomes.Role of translation initiation factor 4G in lifespan regulation and age-related healthThe diverse roles of the eIF4A family: you are the company you keep.A review of craniofacial disorders caused by spliceosomal defects.mRNA metabolism and neuronal disease.Mechanism, factors, and physiological role of nonsense-mediated mRNA decay.The exon junction complex: a lifelong guardian of mRNA fate.Fluorescence Amplification Method for Forward Genetic Discovery of Factors in Human mRNA Degradation.A short conserved motif in ALYREF directs cap- and EJC-dependent assembly of export complexes on spliced mRNAsEmerging roles of calpain proteolytic systems in macrophage cholesterol handling.Control of gene expression through the nonsense-mediated RNA decay pathway.The translational landscape of the splicing factor SRSF1 and its role in mitosis.The Evolutionary Fates of a Large Segmental Duplication in Mouse.Dissection of the factor requirements for spliceosome disassembly and the elucidation of its dissociation products using a purified splicing system.Diabetic polyneuropathy, sensory neurons, nuclear structure and spliceosome alterations: a role for CWC22.Interrogating the degradation pathways of unstable mRNAs with XRN1-resistant sequences.Harnessing short poly(A)-binding protein-interacting peptides for the suppression of nonsense-mediated mRNA decay.The RNA helicase DHX34 activates NMD by promoting a transition from the surveillance to the decay-inducing complex.A specific set of exon junction complex subunits is required for the nuclear retention of unspliced RNAs in Caenorhabditis elegansA role for eIF4AII in microRNA-mediated mRNA silencing.
P2860
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P2860
CWC22 connects pre-mRNA splicing and exon junction complex assembly.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh-hant
name
CWC22 connects pre-mRNA splicing and exon junction complex assembly.
@en
CWC22 connects pre-mRNA splicing and exon junction complex assembly.
@nl
type
label
CWC22 connects pre-mRNA splicing and exon junction complex assembly.
@en
CWC22 connects pre-mRNA splicing and exon junction complex assembly.
@nl
prefLabel
CWC22 connects pre-mRNA splicing and exon junction complex assembly.
@en
CWC22 connects pre-mRNA splicing and exon junction complex assembly.
@nl
P50
P1433
P1476
CWC22 connects pre-mRNA splicing and exon junction complex assembly.
@en
P2093
Agnieszka M Gromadzka
P304
P356
10.1016/J.CELREP.2012.08.017
P577
2012-09-06T00:00:00Z