Renal phenotypic investigations of megalin-deficient patients: novel insights into tubular proteinuria and albumin filtration.
about
Megalin in acute kidney injury: foe and friendUnraveling the Interaction between FcRn and Albumin: Opportunities for Design of Albumin-Based TherapeuticsRediscovering Beta-2 Microglobulin As a Biomarker across the Spectrum of Kidney Diseases.Proximal Tubules Have the Capacity to Regulate Uptake of Albumin.Albuminuria Is an Appropriate Therapeutic Target in Patients with CKD: The Pro View.LRP2, an auxiliary receptor that controls sonic hedgehog signaling in development and disease.Megalin Is Predominantly Observed in Vesicular Structures in First and Third Trimester Cytotrophoblasts of the Human Placenta.Melanoma tumors frequently acquire LRP2/megalin expression, which modulates melanoma cell proliferation and survival rates.Megalin-deficiency causes high myopia, retinal pigment epithelium-macromelanosomes and abnormal development of the ciliary body in mice.Endocytic receptor LRP2/megalin-of holoprosencephaly and renal Fanconi syndrome.Renal uptake of the antiapoptotic protein survivin is mediated by megalin at the apical membrane of the proximal tubule.Lack of megalin expression in adult human terminal ileum suggests megalin-independent cubilin/amnionless activity during vitamin B12 absorptionORAI channels are critical for receptor-mediated endocytosis of albumin.Proximal Tubular Expression Patterns of Megalin and Cubilin in Proteinuric Nephropathies.Tubular reabsorption of high, middle and low molecular weight proteins according to the tubulo-interstitial damage marker N-acetyl-β-D-glucosaminidase in glomerulonephritis.In-depth phenotyping of a Donnai-Barrow patient helps clarify proximal tubule dysfunction.MicroRNA-148b regulates megalin expression and is associated with receptor downregulation in mice with unilateral ureteral obstruction.Monogenic Causes of Proteinuria in Children.The Spectrum of Kidney Diseases in Children Associated with Low Molecular Weight Proteinuria.
P2860
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P2860
Renal phenotypic investigations of megalin-deficient patients: novel insights into tubular proteinuria and albumin filtration.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh-hant
name
Renal phenotypic investigation ...... inuria and albumin filtration.
@en
Renal phenotypic investigation ...... inuria and albumin filtration.
@nl
type
label
Renal phenotypic investigation ...... inuria and albumin filtration.
@en
Renal phenotypic investigation ...... inuria and albumin filtration.
@nl
prefLabel
Renal phenotypic investigation ...... inuria and albumin filtration.
@en
Renal phenotypic investigation ...... inuria and albumin filtration.
@nl
P2093
P356
P1476
Renal phenotypic investigation ...... inuria and albumin filtration.
@en
P2093
Birgitta Sundelin
Carina Frykholm
Erik I Christensen
Gerd Holmström
Henrik Birn
Katharina Ericson
Lisbeth Tranebjærg
Pierre J Verroust
Rikke Nielsen
Tryggve Nevéus
P304
P356
10.1093/NDT/GFS462
P407
P577
2012-10-09T00:00:00Z