Pharmacological targeting of the transcription factor Nrf2 at the basal ganglia provides disease modifying therapy for experimental parkinsonism.
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Sulforaphane as a potential protective phytochemical against neurodegenerative diseasesNatural Phytochemicals in the Treatment and Prevention of Dementia: An OverviewRole of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanismRedox control of microglial function: molecular mechanisms and functional significanceSuppression of the Nrf2-dependent antioxidant response by glucocorticoids and 11β-HSD1-mediated glucocorticoid activation in hepatic cellsSulforaphane protects against rotenone-induced neurotoxicity in vivo: Involvement of the mTOR, Nrf2, and autophagy pathways.Dietary Phytochemicals in Neuroimmunoaging: A New Therapeutic Possibility for Humans?Isothiocyanates Are Promising Compounds against Oxidative Stress, Neuroinflammation and Cell Death that May Benefit Neurodegeneration in Parkinson's DiseaseSmall molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agentsAdaptive cellular stress pathways as therapeutic targets of dietary phytochemicals: focus on the nervous systemMechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative diseaseMetabolism and tissue distribution of sulforaphane in Nrf2 knockout and wild-type miceEnergy intake and exercise as determinants of brain health and vulnerability to injury and diseaseEffects of the antioxidant sulforaphane on hyperlocomotion and prepulse inhibition deficits in mice after phencyclidine administration.Discovery of potent, novel Nrf2 inducers via quantum modeling, virtual screening, and in vitro experimental validation.Transcription factors NRF2 and NF-κB are coordinated effectors of the Rho family, GTP-binding protein RAC1 during inflammation.Modulation of experimental herpes encephalitis-associated neurotoxicity through sulforaphane treatment.Role of oxidative stress in Parkinson's disease.Redox-based therapeutics in neurodegenerative disease.A novel compound VSC2 has anti-inflammatory and antioxidant properties in microglia and in Parkinson's disease animal model.Dietary broccoli mildly improves neuroinflammation in aged mice but does not reduce lipopolysaccharide-induced sickness behaviorA novel synthetic isothiocyanate ITC-57 displays antioxidant, anti-inflammatory, and neuroprotective properties in a mouse Parkinson's disease model.Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/β-TrCP axis.Neuroprotective effects of erucin against 6-hydroxydopamine-induced oxidative damage in a dopaminergic-like neuroblastoma cell line.Thiol-redox signaling, dopaminergic cell death, and Parkinson's diseaseActivation of the Nrf2-ARE pathway by siRNA knockdown of Keap1 reduces oxidative stress and provides partial protection from MPTP-mediated neurotoxicity.Nrf2--a therapeutic target for the treatment of neurodegenerative diseases.Attenuation of β-amyloid-induced oxidative cell death by sulforaphane via activation of NF-E2-related factor 2.Repurposing the NRF2 Activator Dimethyl Fumarate as Therapy Against Synucleinopathy in Parkinson's DiseaseSOD1 and DJ-1 converge at Nrf2 pathway: a clue for antioxidant therapeutic potential in neurodegenerationBioactive Flavonoids and Catechols as Hif1 and Nrf2 Protein Stabilizers - Implications for Parkinson's Disease.Antioxidant gene therapy against neuronal cell death.The emerging role of Nrf2 in mitochondrial functionHyperammonemia induces glial activation, neuroinflammation and alters neurotransmitter receptors in hippocampus, impairing spatial learning: reversal by sulforaphanePotential repositioning of exemestane as a neuroprotective agent for Parkinson's disease.Melatonin as a versatile molecule to design novel multitarget hybrids against neurodegeneration.d,l-Sulforaphane Induces ROS-Dependent Apoptosis in Human Gliomablastoma Cells by Inactivating STAT3 Signaling Pathway.Nrf2 Weaves an Elaborate Network of Neuroprotection Against Stroke.Neuroprotective Effects of Tanshinone I Against 6-OHDA-Induced Oxidative Stress in Cellular and Mouse Model of Parkinson's Disease Through Upregulating Nrf2.Nrf2: a modulator of Parkinson's disease?
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P2860
Pharmacological targeting of the transcription factor Nrf2 at the basal ganglia provides disease modifying therapy for experimental parkinsonism.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh-hant
name
Pharmacological targeting of t ...... for experimental parkinsonism.
@en
Pharmacological targeting of t ...... for experimental parkinsonism.
@nl
type
label
Pharmacological targeting of t ...... for experimental parkinsonism.
@en
Pharmacological targeting of t ...... for experimental parkinsonism.
@nl
prefLabel
Pharmacological targeting of t ...... for experimental parkinsonism.
@en
Pharmacological targeting of t ...... for experimental parkinsonism.
@nl
P2093
P356
P1476
Pharmacological targeting of t ...... for experimental parkinsonism
@en
P2093
Agnieszka Jazwa
Javier Fernández-Ruiz
Marlen Hesse
Nadia G Innamorato
P304
P356
10.1089/ARS.2010.3731
P577
2011-03-28T00:00:00Z