about
Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from ultraviolet-induced apoptosisCathepsin H is an additional convertase of pro-granzyme BSerpinB6 is an inhibitor of kallikrein-8 in keratinocytesSerpins flex their muscle: II. Structural insights into target peptidase recognition, polymerization, and transport functionsSerpins flex their muscle: I. Putting the clamps on proteolysis in diverse biological systemsMaspin is not required for embryonic development or tumour suppressionMaspin (SERPINB5) is an obligate intracellular serpinThe major human and mouse granzymes are structurally and functionally divergentAnalysis of vertebrate genomes suggests a new model for clade B serpin evolution.Brinp1(-/-) mice exhibit autism-like behaviour, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron densityA common fold mediates vertebrate defense and bacterial attackStructure of granzyme C reveals an unusual mechanism of protease autoinhibitionThe structural basis for membrane binding and pore formation by lymphocyte perforinPerforin-independent expression of granzyme B and proteinase inhibitor 9 in human testis and placenta suggests a role for granzyme B-mediated proteolysis in reproductionCharacterization of four murine homologs of the human ov-serpin monocyte neutrophil elastase inhibitor MNEI (SERPINB1)Production and characterization of recombinant human proteinase inhibitor 6 expressed in Pichia pastorisProteinase inhibitor 6 (PI-6) expression in human skin: induction of PI-6 and a PI-6/proteinase complex during keratinocyte differentiationA serpin gene cluster on human chromosome 6p25 contains PI6, PI9 and ELANH2 which have a common structure almost identical to the 18q21 ovalbumin serpin genesChromosomal mapping of the human proteinase inhibitor 6 (PI6) gene to 6p25 by fluorescence in situ hybridizationA natural genetic variant of granzyme B confers lethality to a common viral infectionDistinct membrane and cytosolic forms of inositol polyphosphate 5-phosphatase II. Efficient membrane localization requires two discrete domainsGene structure, chromosomal localization, and expression of the murine homologue of human proteinase inhibitor 6 (PI-6) suggests divergence of PI-6 from the ovalbumin serpinsRNA-Seq analysis of chikungunya virus infection and identification of granzyme A as a major promoter of arthritic inflammationThe serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclatureThe MACPF/CDC family of pore-forming toxins.Characterization of Lgr5+ progenitor cell transcriptomes in the apical and basal turns of the mouse cochlea.Mice Lacking Brinp2 or Brinp3, or Both, Exhibit Behaviors Consistent with Neurodevelopmental Disorders.Cytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis.Granzyme B triggers a prolonged pressure to die in Bcl-2 overexpressing cells, defining a window of opportunity for effective treatment with ABT-737Mouse granzyme A induces a novel death with writhing morphology that is mechanistically distinct from granzyme B-induced apoptosisZebrafish models for nemaline myopathy reveal a spectrum of nemaline bodies contributing to reduced muscle functionIdentification of AHNAK as a novel autoantigen in systemic lupus erythematosus.Alpha1A- and alpha1B-adrenoceptors are the major subtypes in human saphenous vein.Elucidation of the substrate specificity of the C1s protease of the classical complement pathway.Elucidation of the substrate specificity of the MASP-2 protease of the lectin complement pathway and identification of the enzyme as a major physiological target of the serpin, C1-inhibitor.The effects of exosite occupancy on the substrate specificity of thrombin.Regulation of pro-apoptotic leucocyte granule serine proteinases by intracellular serpins.Cationic sites on granzyme B contribute to cytotoxicity by promoting its uptake into target cells.Predicting serpin/protease interactions.Perforin evolved from a gene duplication of MPEG1, followed by a complex pattern of gene gain and loss within Euteleostomi
P50
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P50
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researcher
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wetenschapper
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հետազոտող
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Phillip I Bird
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Phillip I Bird
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Phillip I Bird
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Phillip I Bird
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Phillip I Bird
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Phillip I Bird
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Phillip I Bird
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Phillip I Bird
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Phillip I Bird
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Phillip I Bird
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Phillip Ian Bird
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Phillip I Bird
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Phillip I Bird
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Phillip I Bird
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Phillip I Bird
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Phillip I Bird
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P106
P1153
55748837900
P31
P496
0000-0002-6695-606X