Semisimultaneous Midazolam Administration to Evaluate the Time Course of CYP3A Activation by a Single Oral Dose of Efavirenz.

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Addressing Antiretroviral Therapy-Associated Drug-Drug Interactions in Patients Requiring Treatment for Opportunistic Infections in Low-Income and Resource-Limited Settings.Allosteric activation of cytochrome P450 3A4 by efavirenz facilitates midazolam binding.

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Semisimultaneous Midazolam Administration to Evaluate the Time Course of CYP3A Activation by a Single Oral Dose of Efavirenz.

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2017 nî lūn-bûn

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2017年の論文

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Semisimultaneous Midazolam Adm ...... Single Oral Dose of Efavirenz.

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Semisimultaneous Midazolam Adm ...... Single Oral Dose of Efavirenz.

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Semisimultaneous Midazolam Adm ...... Single Oral Dose of Efavirenz.

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Semisimultaneous Midazolam Adm ...... Single Oral Dose of Efavirenz.

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Semisimultaneous Midazolam Adm ...... Single Oral Dose of Efavirenz.

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Anne-Kathrin Matthee

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Claudia Röder

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Johanna Weiss

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Julia Bödigheimer

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Jürgen Burhenne

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Tilman Heinrich

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Walter E Haefeli

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P2860

Inhibition of human cytochrome P450 isoforms by nonnucleoside reverse transcriptase inhibitors.

The erythromycin breath test reflects P-glycoprotein function independently of cytochrome P450 3A activity.

Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers

No evidence for induction of ABC transporters in peripheral blood mononuclear cells in humans after 14 days of efavirenz treatment.

Contribution of N-glucuronidation to efavirenz elimination in vivo in the basal and rifampin-induced metabolism of efavirenz.

Efavirenz: a review.

Induction of CYP2C19 and CYP3A activity following repeated administration of efavirenz in healthy volunteers.

Impact of efavirenz on intestinal metabolism and transport: insights from an interaction study with ezetimibe in healthy volunteers.

CYP3A activity: towards dose adaptation to the individual.

Induction of multiple drug transporters by efavirenz.

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scholarly article

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10.1002/JCPH.879

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Semisimultaneous Midazolam Administration to Evaluate the Time Course of CYP3A Activation by a Single Oral Dose of Efavirenz.

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P2860

P2860

Semisimultaneous Midazolam Administration to Evaluate the Time Course of CYP3A Activation by a Single Oral Dose of Efavirenz.

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