T/B lineage choice occurs prior to intrathymic Notch signaling.
about
Progression of regulatory gene expression states in fetal and adult pro-T-cell development.Specific bone cells produce DLL4 to generate thymus-seeding progenitors from bone marrow.Primitive lymphoid progenitors in bone marrow with T lineage reconstituting potential.Notch-dependent T-lineage commitment occurs at extrathymic sites following bone marrow transplantation.Notch, Id2, and RORγt sequentially orchestrate the fetal development of lymphoid tissue inducer cells.Global transcriptional analysis of primitive thymocytes reveals accelerated dynamics of T cell specification in fetal stagesE proteins and Notch signaling cooperate to promote T cell lineage specification and commitment.Establishment and functioning of intrathymic microenvironments.Cellular and molecular events during early thymus development.Regulation of intrathymic T-cell development by Lunatic Fringe- Notch1 interactions.At the crossroads: diverse roles of early thymocyte transcriptional regulators.From stem cell to T cell: one route or many?Journey through the thymus: stromal guides for T-cell development and selection.Notch and Wnt signaling in T-lymphocyte development and acute lymphoblastic leukemia.Canonical notch signaling is dispensable for the maintenance of adult hematopoietic stem cellsCompetition and collaboration: GATA-3, PU.1, and Notch signaling in early T-cell fate determination.Clonal analysis reveals uniformity in the molecular profile and lineage potential of CCR9(+) and CCR9(-) thymus-settling progenitors.Initial seeding of the embryonic thymus by immune-restricted lympho-myeloid progenitorsThe role of notch signaling in the development of a normal B-cell repertoire.Multilayered specification of the T-cell lineage fate.T cell lineage commitment: identity and renunciation.Transcriptional control of early T and B cell developmental choicesForging T-Lymphocyte Identity: Intersecting Networks of Transcriptional Control.The functional relationship between hematopoietic stem cells and developing T lymphocytes.Medullary thymic epithelial stem cells: role in thymic epithelial cell maintenance and thymic involution.Two waves of distinct hematopoietic progenitor cells colonize the fetal thymus.The Human Thymus Is Enriched for Autoreactive B Cells.Identification of a T lineage-committed progenitor in adult blood.Delta-like 4 is indispensable in thymic environment specific for T cell developmentClonal analysis reveals a common progenitor for thymic cortical and medullary epithelium.Requirement for Notch1 signals at sequential early stages of intrathymic T cell development.DL4-mediated Notch signaling is required for the development of fetal αβ and γδ T cells.
P2860
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P2860
T/B lineage choice occurs prior to intrathymic Notch signaling.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh-hant
name
T/B lineage choice occurs prior to intrathymic Notch signaling.
@en
T/B lineage choice occurs prior to intrathymic Notch signaling.
@nl
type
label
T/B lineage choice occurs prior to intrathymic Notch signaling.
@en
T/B lineage choice occurs prior to intrathymic Notch signaling.
@nl
prefLabel
T/B lineage choice occurs prior to intrathymic Notch signaling.
@en
T/B lineage choice occurs prior to intrathymic Notch signaling.
@nl
P2093
P1433
P1476
T/B lineage choice occurs prior to intrathymic Notch signaling.
@en
P2093
Benjamin C Harman
Eric J Jenkinson
Graham Anderson
Simona W Rossi
Sonia M Parnell
William E Jenkinson
P304
P356
10.1182/BLOOD-2004-12-4881
P407
P577
2005-04-21T00:00:00Z