Several inhibitors of the Plk1 Polo-Box Domain turn out to be non-specific protein alkylators.

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Current progress and future perspectives in the development of anti-polo-like kinase 1 therapeutic agents.Modulating Protein-Protein Interactions of the Mitotic Polo-like Kinases to Target Mutant KRAS.The Emerging Role of Polo-Like Kinase 1 in Epithelial-Mesenchymal Transition and Tumor Metastasis.

P2860

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P2860

Several inhibitors of the Plk1 Polo-Box Domain turn out to be non-specific protein alkylators.

Item

http://www.wikidata.org/entity/Q50994164

description

2017 nî lūn-bûn

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2017年の論文

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2017年学术文章

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2017年学术文章

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2017年学术文章

@zh-cn

2017年学术文章

@zh-hans

2017年学术文章

@zh-my

2017年学术文章

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2017年學術文章

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2017年學術文章

@zh-hant

name

Several inhibitors of the Plk1 ...... n-specific protein alkylators.

@en

Several inhibitors of the Plk1 ...... n-specific protein alkylators.

@nl

type

Item

label

Several inhibitors of the Plk1 ...... n-specific protein alkylators.

@en

Several inhibitors of the Plk1 ...... n-specific protein alkylators.

@nl

prefLabel

Several inhibitors of the Plk1 ...... n-specific protein alkylators.

@en

Several inhibitors of the Plk1 ...... n-specific protein alkylators.

@nl

P1476

Several inhibitors of the Plk1 ...... n-specific protein alkylators.

@en

P2093

Karine Normandin

http://www.w3.org/2001/XMLSchema#string

Vincent Archambault

http://www.w3.org/2001/XMLSchema#string

P2860

A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene

Discovery and development of the Polo-like kinase inhibitor volasertib in cancer therapy

The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain

BI 6727, a Polo-like kinase inhibitor with improved pharmacokinetic profile and broad antitumor activity

Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel

Identification of High Affinity Polo-like Kinase 1 (Plk1) Polo-box Domain Binding Peptides Using Oxime-Based Diversification

Thymoquinone blocks pSer/pThr recognition by Plk1 Polo-box domain as a phosphate mimic

Structural basis for the inhibition of Polo-like kinase 1

Identification of Polo-like kinase 1 interaction inhibitors using a novel cell-based assay

New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays

P304

1220-1224

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P31

scholarly article

P356

10.1080/15384101.2017.1325043

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P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

P577

2017-05-19T00:00:00Z

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P698

28521657

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P932

5499904

http://www.w3.org/2001/XMLSchema#string

Several inhibitors of the Plk1 Polo-Box Domain turn out to be non-specific protein alkylators.

about

P2860

P2860

Several inhibitors of the Plk1 Polo-Box Domain turn out to be non-specific protein alkylators.

description

name

type

label

prefLabel

P1433

P1476

P2093

P2860

P304

P31

P356

P433

P478

P577

P698

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P433

P478

P577

P698

P932