LY354740, a potent group II metabotropic glutamate receptor agonist prevents lactate-induced panic-like response in panic-prone rats.
about
Chronic inhibition of GABA synthesis in the bed nucleus of the stria terminalis elicits anxiety-like behaviorAn animal model of panic vulnerability with chronic disinhibition of the dorsomedial/perifornical hypothalamusInteroception and learning: import to understanding and treating diseases and psychopathologiesEtiology, triggers and neurochemical circuits associated with unexpected, expected, and laboratory-induced panic attacksAdvances in the treatment of anxiety: targeting glutamate.A key role for orexin in panic anxiety.Activation of group II metabotropic glutamate receptors induces depotentiation in amygdala slices and reduces fear-potentiated startle in rats.The role of glutamate in anxiety and related disorders.Changes in central sodium and not osmolarity or lactate induce panic-like responses in a model of panic disorderModeling panic disorder in rodents.Disruption of GABAergic tone in the dorsomedial hypothalamus attenuates responses in a subset of serotonergic neurons in the dorsal raphe nucleus following lactate-induced panic.Group II metabotropic glutamate receptor type 2 allosteric potentiators prevent sodium lactate-induced panic-like response in panic-vulnerable rats.Emerging targets for the treatment of depressive disorder.Role of progesterone and other neuroactive steroids in anxiety disorders.Orexin, stress, and anxiety/panic states.Emerging drugs for panic disorder.Novel investigational therapeutics for panic disorder.The role of group II metabotropic glutamate receptors in cognition and anxiety: comparative studies in GRM2(-/-), GRM3(-/-) and GRM2/3(-/-) knockout mice.Anxiolytic activity of the MGLU2/3 receptor agonist LY354740 on the elevated plus maze is associated with the suppression of stress-induced c-Fos in the hippocampus and increases in c-Fos induction in several other stress-sensitive brain regions.Bidirectional regulation of synaptic plasticity in the basolateral amygdala induced by the D1-like family of dopamine receptors and group II metabotropic glutamate receptors.
P2860
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P2860
LY354740, a potent group II metabotropic glutamate receptor agonist prevents lactate-induced panic-like response in panic-prone rats.
description
2000 nî lūn-bûn
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name
LY354740, a potent group II me ...... response in panic-prone rats.
@en
LY354740, a potent group II me ...... response in panic-prone rats.
@nl
type
label
LY354740, a potent group II me ...... response in panic-prone rats.
@en
LY354740, a potent group II me ...... response in panic-prone rats.
@nl
prefLabel
LY354740, a potent group II me ...... response in panic-prone rats.
@en
LY354740, a potent group II me ...... response in panic-prone rats.
@nl
P1433
P1476
LY354740, a potent group II me ...... response in panic-prone rats.
@en
P2093
P304
P356
10.1016/S0028-3908(99)00215-4
P577
2000-04-01T00:00:00Z