about
Convergent chemical synthesis and high-resolution x-ray structure of human lysozymeStructure of Rab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPaseChemical synthesis and structure of the prokineticin Bv8Efficient chemical synthesis of human complement protein C3aChemical engineering and structural and pharmacological characterization of the α-scorpion toxin OD1Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2Isolation and structural and pharmacological characterization of α-elapitoxin-Dpp2d, an amidated three finger toxin from black mamba venomProtein semi-synthesis: new proteins for functional and structural studies.Structure of doubly prenylated Ypt1:GDI complex and the mechanism of GDI-mediated Rab recycling.Intein-mediated synthesis of geranylgeranylated Rab7 protein in vitro.Application of protein semisynthesis for the construction of functionalized posttranslationally modified rab GTPases.The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.Chemical biology of protein lipidation: semi-synthesis and structure elucidation of prenylated RabGTPases.Modulation of human Nav1.7 channel gating by synthetic α-scorpion toxin OD1 and its analogs.Mapping of voltage sensor positions in resting and inactivated mammalian sodium channels by LRET.Disulfide-rich macrocyclic peptides as templates in drug design.Therapeutic conotoxins: a US patent literature survey.Europium-Labeled Synthetic C3a Protein as a Novel Fluorescent Probe for Human Complement C3a Receptor.Nicotiana alata Defensin Chimeras Reveal Differences in the Mechanism of Fungal and Tumor Cell Killing and an Enhanced Antifungal Variant.Constrained Cyclic Peptides as Immunomodulatory Inhibitors of the CD2:CD58 Protein-Protein Interaction.Approaches to the stabilization of bioactive epitopes by grafting and peptide cyclization.Cyclic alpha-conotoxin peptidomimetic chimeras as potent GLP-1R agonists.Characterisation of Na(v) types endogenously expressed in human SH-SY5Y neuroblastoma cells.Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain.Efficient backbone cyclization of linear peptides by a recombinant asparaginyl endopeptidase.Synthesis of fluorescently labeled mono- and diprenylated Rab7 GTPase.Solid phase synthesis of peptide-selenoesters.Isolation, synthesis and characterization of ω-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type Cav channels.Combining Sense and Nonsense Codon Reassignment for Site-Selective Protein Modification with Unnatural Amino Acids.Interaction of Synthetic Human SLURP-1 with the Nicotinic Acetylcholine Receptors.Co-expression of a cyclizing asparaginyl endopeptidase enables efficient production of cyclic peptides in planta.The E15R Point Mutation in Scorpion Toxin Cn2 Uncouples Its Depressant and Excitatory Activities on Human NaV1.6.Chemical synthesis and folding of APETx2, a potent and selective inhibitor of acid sensing ion channel 3.Isolation of two insecticidal toxins from venom of the Australian theraphosid spider Coremiocnemis tropix.Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1.Potent complement C3a receptor agonists derived from oxazole amino acids: Structure-activity relationships.Fmoc-based synthesis of disulfide-rich cyclic peptides.Molecular basis for the production of cyclic peptides by plant asparaginyl endopeptidases.Targeted Delivery of Cyclotides via Conjugation to a NanobodySynthesis of Functionalized Rab GTPases by a Combination of Solution- or Solid-Phase Lipopeptide Synthesis with Expressed Protein Ligation
P50
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P50
description
biochemicus
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հետազոտող
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name
Thomas Durek
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Thomas Durek
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Thomas Durek
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Thomas Durek
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Thomas Durek
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Thomas Durek
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type
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Thomas Durek
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Thomas Durek
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Thomas Durek
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Thomas Durek
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Thomas Durek
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Thomas Durek
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prefLabel
Thomas Durek
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Thomas Durek
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Thomas Durek
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Thomas Durek
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Thomas Durek
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Thomas Durek
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P227
P1053
I-8715-2014
P1153
6505920609
P21
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P227
1168594278
P31
P3829
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0000-0003-0686-227X
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