about
Mastering the canonical loop of serine protease inhibitors: enhancing potency by optimising the internal hydrogen bond networkDirect and indirect mechanisms of KLK4 inhibition revealed by structure and dynamics.Substrate-guided design of a potent and selective kallikrein-related peptidase inhibitor for kallikrein 4.Non-combinatorial library screening reveals subsite cooperativity and identifies new high-efficiency substrates for kallikrein-related peptidase 14.Improving the Selectivity of Engineered Protease Inhibitors: Optimizing the P2 Prime Residue Using a Versatile Cyclic Peptide Library.Exploring the active site binding specificity of kallikrein-related peptidase 5 (KLK5) guides the design of new peptide substrates and inhibitors.Design of Potent and Selective Cathepsin G Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold.Transgenic kallikrein 5 mice reproduce major cutaneous and systemic hallmarks of Netherton syndrome.Proteases: common culprits in human skin disorders.A new TRPV3 missense mutation in a patient with Olmsted syndrome and erythromelalgia.Proteases and proteomics: cutting to the core of human skin pathologies.Kallikrein-Related Peptidase 5 Contributes to H3N2 Influenza Virus Infection in Human Lungs.Selective cleavage of human sex hormone-binding globulin by kallikrein-related peptidases and effects on androgen action in LNCaP prostate cancer cells.Substrate-Guided Design of Selective FXIIa Inhibitors Based on the Plant-Derived Momordica cochinchinensis Trypsin Inhibitor-II (MCoTI-II) Scaffold.Cyclotides as Tools in Chemical Biology.Selective Substrates and Inhibitors for Kallikrein-Related Peptidase 7 (KLK7) Shed Light on KLK Proteolytic Activity in the Stratum Corneum.Attenuated kallikrein-related peptidase activity disrupts desquamation and leads to stratum corneum thickening in human skin equivalent models.Engineered protease inhibitors based on sunflower trypsin inhibitor-1 (SFTI-1) provide insights into the role of sequence and conformation in Laskowski mechanism inhibition.Mechanism-based selection of a potent kallikrein-related peptidase 7 inhibitor from a versatile library based on the sunflower trypsin inhibitor SFTI-1Potent, multi-target serine protease inhibition achieved by a simplified β-sheet motifOlmsted syndrome with erythromelalgia caused by recessive transient receptor potential vanilloid 3 mutationsEngineering potent mesotrypsin inhibitors based on the plant-derived cyclic peptide, sunflower trypsin inhibitor-1Potent, Selective, and Cell-Penetrating Inhibitors of Kallikrein-Related Peptidase 4 Based on the Cyclic Peptide MCoTI-IICharacterising the Subsite Specificity of Urokinase-Type Plasminogen Activator and Tissue-Type Plasminogen Activator using a Sequence-Defined Peptide Aldehyde LibraryKLK4 Inhibition by Cyclic and Acyclic Peptides: Structural and Dynamical Insights into Standard-Mechanism Protease InhibitorsCyclotides: From Structure to FunctionBinding Loop Substitutions in the Cyclic Peptide SFTI-1 Generate Potent and Selective Chymase InhibitorsAmino Acid Scanning at P5' within the Bowman-Birk Inhibitory Loop Reveals Specificity Trends for Diverse Serine ProteasesIterative Optimization of the Cyclic Peptide SFTI-1 Yields Potent Inhibitors of Neutrophil Proteinase 3
P50
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P50
description
hulumtues
@sq
onderzoeker
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researcher
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հետազոտող
@hy
name
Simon J de Veer
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Simon J de Veer
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Simon J de Veer
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Simon J de Veer
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Simon J de Veer
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type
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Simon J de Veer
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Simon J de Veer
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Simon J de Veer
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Simon J de Veer
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Simon J de Veer
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prefLabel
Simon J de Veer
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Simon J de Veer
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Simon J de Veer
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Simon J de Veer
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Simon J de Veer
@sl
P106
P21
P31
P496
0000-0002-7041-9937