about
PTEN as an effector in the signaling of antimigratory G protein-coupled receptorEndogenous S-nitrosothiols protect against myocardial injuryAllelic and locus heterogeneity in inherited venous malformationsFunctional significance of Tie2 signaling in the adult vasculatureVEGF and soluble VEGF receptor-1 (sFlt-1) distributions in peripheral arterial disease: an in silico model.HCPTPA, a protein tyrosine phosphatase that regulates vascular endothelial growth factor receptor-mediated signal transduction and biological activity.In mice with type 2 diabetes, a vascular endothelial growth factor (VEGF)-activating transcription factor modulates VEGF signaling and induces therapeutic angiogenesis after hindlimb ischemia.Inhibition of in vivo tumor angiogenesis and growth via systemic delivery of an angiopoietin 2-specific RNA aptamer.A nuclease-resistant RNA aptamer specifically inhibits angiopoietin-1-mediated Tie2 activation and functionAngiopoietin-2 confers Atheroprotection in apoE-/- mice by inhibiting LDL oxidation via nitric oxide.Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculatureThe endothelial receptor tyrosine kinase Tie1 activates phosphatidylinositol 3-kinase and Akt to inhibit apoptosis.A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension.Negative regulation of myofibroblast differentiation by PTEN (Phosphatase and Tensin Homolog Deleted on chromosome 10)Angiopoietin-1 enhances skeletal muscle regeneration in mice.In vivo tumor targeting by a NGR-decorated micelle of a recombinant diblock copolypeptideMuscle cell derived angiopoietin-1 contributes to both myogenesis and angiogenesis in the ischemic environment.Gene therapy for the prevention of vein graft diseaseDeletion of the carboxyl terminus of Tie2 enhances kinase activity, signaling, and function. Evidence for an autoinhibitory mechanism.H1 RNA polymerase III promoter-driven expression of an RNA aptamer leads to high-level inhibition of intracellular protein activity.RNA aptamer-targeted inhibition of NF-kappa B suppresses non-small cell lung cancer resistance to doxorubicin.Subacute limb ischemia induces skeletal muscle injury in genetically susceptible mice independent of vascular densityPhosphatase and tensin homolog (PTEN) regulates hepatic lipogenesis, microsomal triglyceride transfer protein, and the secretion of apolipoprotein B-containing lipoproteins.More than skin deep: connecting melanocyte pigmentation and angiogenic diseases.Modulation of phosphatidylinositol 3-kinase signaling reduces intimal hyperplasia in aortocoronary saphenous vein grafts.VEGF induces Tie2 shedding via a phosphoinositide 3-kinase/Akt dependent pathway to modulate Tie2 signaling.Up-regulating sphingosine 1-phosphate receptor-2 signaling impairs chemotactic, wound-healing, and morphogenetic responses in senescent endothelial cells.Inhibiting the inhibitor: targeting vascular endothelial protein tyrosine phosphatase to promote tumor vascular maturation.A VEGF trap inhibits the beneficial effect of bFGF on vasoreactivity in corporal tissues of hypercholesterolemic rabbits.Endothelin-1 activates endothelial cell nitric-oxide synthase via heterotrimeric G-protein betagamma subunit signaling to protein jinase B/Akt.Acute local subcutaneous VEGF165 injection for augmentation of skin flap viability: efficacy and mechanism.IQGAP1, a novel vascular endothelial growth factor receptor binding protein, is involved in reactive oxygen species--dependent endothelial migration and proliferation.Adenovirus-mediated intraarterial delivery of PTEN inhibits neointimal hyperplasia.Efficacy and mechanism of adenovirus-mediated VEGF-165 gene therapy for augmentation of skin flap viability.High cholesterol feeding in C57/Blc6 mice alters expression within the VEGF receptor-ligand family in corporal tissue.Cholesterol feeding reduces vascular endothelial growth factor signaling in rabbit corporal tissues.Engineered zinc finger-activating vascular endothelial growth factor transcription factor plasmid DNA induces therapeutic angiogenesis in rabbits with hindlimb ischemia.Systemic overexpression of angiopoietin-2 promotes tumor microvessel regression and inhibits angiogenesis and tumor growthSystemic soluble Tie2 expression inhibits and regresses corneal neovascularizationPTEN modulates vascular endothelial growth factor-mediated signaling and angiogenic effects
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Christopher D Kontos
@nl
Christopher D Kontos
@sl
Christopher D. Kontos
@en
Christopher D. Kontos
@es
type
label
Christopher D Kontos
@nl
Christopher D Kontos
@sl
Christopher D. Kontos
@en
Christopher D. Kontos
@es
prefLabel
Christopher D Kontos
@nl
Christopher D Kontos
@sl
Christopher D. Kontos
@en
Christopher D. Kontos
@es
P106
P1153
6603366721
P21
P31
P496
0000-0002-8056-3115