Unbound liver concentration is the true inhibitor concentration that determines cytochrome P450-mediated drug-drug interactions in rat liver.

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Quantitative prediction of the extent of drug-drug interaction using a physiologically based pharmacokinetic model that includes inhibition of drug metabolism determined in cryopreserved hepatocytes.

P2860

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Unbound liver concentration is the true inhibitor concentration that determines cytochrome P450-mediated drug-drug interactions in rat liver.

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2016 nî lūn-bûn

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2016年の論文

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2016年学术文章

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2016年学术文章

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2016年学术文章

@zh-cn

2016年学术文章

@zh-hans

2016年学术文章

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2016年学术文章

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2016年學術文章

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2016年學術文章

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name

Unbound liver concentration is ...... rug interactions in rat liver.

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Unbound liver concentration is ...... rug interactions in rat liver.

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type

Item

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Unbound liver concentration is ...... rug interactions in rat liver.

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Unbound liver concentration is ...... rug interactions in rat liver.

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Unbound liver concentration is ...... rug interactions in rat liver.

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Unbound liver concentration is ...... rug interactions in rat liver.

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Unbound liver concentration is ...... rug interactions in rat liver.

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P2093

Hideki Hirabayashi

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Miyuki Funami

http://www.w3.org/2001/XMLSchema#string

Nobuyuki Amano

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Shinji Iwasaki

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P2860

Quantitative prediction of in vivo drug interactions between nevirapine and antifungal agents from in vitro data in rats.

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Prediction of CYP2C9-mediated drug-drug interactions: a comparison using data from recombinant enzymes and human hepatocytes.

The utility of in vitro cytochrome P450 inhibition data in the prediction of drug-drug interactions.

Prediction of in vivo drug-drug interactions from in vitro data : factors affecting prototypic drug-drug interactions involving CYP2C9, CYP2D6 and CYP3A4.

Quantitative prediction of in vivo drug clearance and drug interactions from in vitro data on metabolism, together with binding and transport.

Mechanism-based inhibition of cytochrome P450 3A4 by therapeutic drugs.

Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions.

Drug-drug interaction studies: regulatory guidance and an industry perspective

New era in drug interaction evaluation: US Food and Drug Administration update on CYP enzymes, transporters, and the guidance process.

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488-497

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scholarly article

P356

10.1080/00498254.2016.1204485

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English

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2016-07-20T00:00:00Z

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P698

27435455

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Unbound liver concentration is the true inhibitor concentration that determines cytochrome P450-mediated drug-drug interactions in rat liver.

about

P2860

P2860

Unbound liver concentration is the true inhibitor concentration that determines cytochrome P450-mediated drug-drug interactions in rat liver.

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