Inducible expression of mutant human DISC1 in mice is associated with brain and behavioral abnormalities reminiscent of schizophrenia.
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Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signalingMutant mouse models: genotype-phenotype relationships to negative symptoms in schizophreniaDISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphismsFrom Linkage Studies to Epigenetics: What We Know and What We Need to Know in the Neurobiology of SchizophreniaDISC1: a key lead in studying cortical development and associated brain disordersWnt signaling in neuropsychiatric disorders: ties with adult hippocampal neurogenesis and behaviorDISC1 mouse models as a tool to decipher gene-environment interactions in psychiatric disordersImpact of prenatal environmental stress on cortical developmentMissense mutation in DISC1 C-terminal coiled-coil has GSK3β signaling and sex-dependent behavioral effects in miceMutation of Semaphorin-6A disrupts limbic and cortical connectivity and models neurodevelopmental psychopathologyRole for neonatal D-serine signaling: prevention of physiological and behavioral deficits in adult Pick1 knockout mice.Gene × Environment Interactions in Schizophrenia: Evidence from Genetic Mouse ModelsSchizophrenia is associated with dysregulation of a Cdk5 activator that regulates synaptic protein expression and cognition.CAMDI, a novel disrupted in schizophrenia 1 (DISC1)-binding protein, is required for radial migrationThe AAA+ ATPase Thorase regulates AMPA receptor-dependent synaptic plasticity and behaviorDISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212Dixdc1 is a critical regulator of DISC1 and embryonic cortical developmentThe adaptive significance of adult neurogenesis: an integrative approachChlorovirus ATCV-1 is part of the human oropharyngeal virome and is associated with changes in cognitive functions in humans and mice.Animal models of neuropsychiatric disordersAnimal models of gene-environment interaction in schizophrenia: A dimensional perspective.Early postnatal GABAA receptor modulation reverses deficits in neuronal maturation in a conditional neurodevelopmental mouse model of DISC1.Inhibition of protein translation by the DISC1-Boymaw fusion gene from a Scottish family with major psychiatric disorders.Sex differences in animal models of psychiatric disorders.S-SCAM, a rare copy number variation gene, induces schizophrenia-related endophenotypes in transgenic mouse model.Genetic and pharmacological evidence for schizophrenia-related Disc1 interaction with GSK-3.Potential primary roles of glial cells in the mechanisms of psychiatric disorders.Chronic exposure of mutant DISC1 mice to lead produces sex-dependent abnormalities consistent with schizophrenia and related mental disorders: a gene-environment interaction study.Neurodevelopmental animal models of schizophrenia: role in novel drug discovery and developmentSchizophrenia and Depression Co-Morbidity: What We have Learned from Animal Models.Mouse models of gene-environment interactions in schizophrenia.Mice with a naturally occurring DISC1 mutation display a broad spectrum of behaviors associated to psychiatric disorders.Subcortical dopaminergic deficits in a DISC1 mutant model: a study in direct reference to human molecular brain imaging.Pathogenic disruption of DISC1-serine racemase binding elicits schizophrenia-like behavior via D-serine depletion.GABA transporter-1 deficiency confers schizophrenia-like behavioral phenotypes.Is lead exposure in early life an environmental risk factor for Schizophrenia? Neurobiological connections and testable hypotheses.Prenatal infection and schizophrenia: a review of epidemiologic and translational studies.Preweaning sensorimotor deficits and adolescent hypersociability in Grin1 knockdown mice.Animal models of schizophrenia.
P2860
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P2860
Inducible expression of mutant human DISC1 in mice is associated with brain and behavioral abnormalities reminiscent of schizophrenia.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh-hant
name
Inducible expression of mutant ...... reminiscent of schizophrenia.
@en
Inducible expression of mutant ...... reminiscent of schizophrenia.
@nl
type
label
Inducible expression of mutant ...... reminiscent of schizophrenia.
@en
Inducible expression of mutant ...... reminiscent of schizophrenia.
@nl
prefLabel
Inducible expression of mutant ...... reminiscent of schizophrenia.
@en
Inducible expression of mutant ...... reminiscent of schizophrenia.
@nl
P2093
P356
P1433
P1476
Inducible expression of mutant ...... reminiscent of schizophrenia.
@en
P2093
Nikolskaia O
Ovanesov MV
Pletnikov MV
P2888
P304
173-86, 115
P356
10.1038/SJ.MP.4002079
P407
P577
2007-09-11T00:00:00Z