The availability of glucose to CHO cells affects the intracellular lipid-linked oligosaccharide distribution, site occupancy and the N-glycosylation profile of a monoclonal antibody.
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Biochemical Characterization of Human Anti-Hepatitis B Monoclonal Antibody Produced in the Microalgae Phaeodactylum tricornutumN-glycosylation of cholera toxin B subunit in Nicotiana benthamiana: impacts on host stress response, production yield and vaccine potential.Understanding and Controlling Sialylation in a CHO Fc-Fusion Process.The therapeutic monoclonal antibody market.Tailoring recombinant protein quality by rational media design.Low glucose concentrations within typical industrial operating conditions have minimal effect on the transcriptome of recombinant CHO cells.A semi-empirical glycosylation model of a camelid monoclonal antibody under hypothermia cell culture conditions.Glycosylation of monoclonal antibody products: Current status and future prospects.Modulation and modeling of monoclonal antibody N-linked glycosylation in mammalian cell perfusion reactors.Amino acid and glucose metabolism in fed-batch CHO cell culture affects antibody production and glycosylation.A theoretical estimate for nucleotide sugar demand towards Chinese Hamster Ovary cellular glycosylation.Low glucose depletes glycan precursors, reduces site occupancy and galactosylation of a monoclonal antibody in CHO cell culture.A simultaneous assessment metric for MAb quantity and glycan quality.Main Quality Attributes of Monoclonal Antibodies and Effect of Cell Culture ComponentsManganese increases high mannose glycoform on monoclonal antibody expressed in CHO when glucose is absent or limiting: Implications for use of alternate sugars.Site-specific monitoring of N-Glycosylation profiles of a CTLA4-Fc-fusion protein from the secretory pathway to the extracellular environment.Solid-Phase Enzymatic Remodeling Produces High Yields of Single Glycoform Antibodies.Animal Cell Expression Systems.Unravelling Immunoglobulin G Fc N-Glycosylation: A Dynamic Marker Potentiating Predictive, Preventive and Personalised Medicine.Combining metabolic and process engineering strategies to improve recombinant glycoprotein production and quality.Microheterogeneity of Recombinant Antibodies: Analytics and Functional Impact.Engineer Medium and Feed for Modulating N-Glycosylation of Recombinant Protein Production in CHO Cell Culture.Cooperative roles of glucose and asparagine-linked glycosylation in T-type calcium channel expression.Valeric acid induces cell cycle arrest at G1 phase in CHO cell cultures and improves recombinant antibody productivity.A multi-pronged investigation into the effect of glucose starvation and culture duration on fed-batch CHO cell culture.An oligosaccharyltransferase from Leishmania major increases the N-glycan occupancy on recombinant glycoproteins produced in Nicotiana benthamiana.High glucose and low specific cell growth but not mild hypothermia improve specific r-protein productivity in chemostat culture of CHO cells
P2860
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P2860
The availability of glucose to CHO cells affects the intracellular lipid-linked oligosaccharide distribution, site occupancy and the N-glycosylation profile of a monoclonal antibody.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年学术文章
@wuu
2013年学术文章
@zh
2013年学术文章
@zh-cn
2013年学术文章
@zh-hans
2013年学术文章
@zh-my
2013年学术文章
@zh-sg
2013年學術文章
@yue
2013年學術文章
@zh-hant
name
The availability of glucose to ...... file of a monoclonal antibody.
@en
The availability of glucose to ...... file of a monoclonal antibody.
@nl
type
label
The availability of glucose to ...... file of a monoclonal antibody.
@en
The availability of glucose to ...... file of a monoclonal antibody.
@nl
prefLabel
The availability of glucose to ...... file of a monoclonal antibody.
@en
The availability of glucose to ...... file of a monoclonal antibody.
@nl
P2093
P921
P1476
The availability of glucose to ...... file of a monoclonal antibody.
@en
P2093
Erica Lattová
Hélène Perreault
John Doering
Maureen Spearman
P356
10.1016/J.JBIOTEC.2013.11.007
P577
2013-11-25T00:00:00Z