Combined polymorphisms in genes encoding the inflammasome components NALP3 and CARD8 confer susceptibility to Crohn's disease in Swedish men. - Wikidata - wikimedia - TriplyDB

Combined polymorphisms in genes encoding the inflammasome components NALP3 and CARD8 confer susceptibility to Crohn's disease in Swedish men.

Combined polymorphisms in genes encoding the inflammasome components NALP3 and CARD8 confer susceptibility to Crohn's disease in Swedish men.

http://www.wikidata.org/entity/Q51752126

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Mitochondrial dysfunction in inflammatory bowel disease Intestinal barrier in inflammatory bowel disease Inflammasome in intestinal inflammation and cancer The role of innate immunity receptors in the pathogenesis of inflammatory bowel disease The structure of the CARD8 caspase-recruitment domain suggests its association with the FIIND domain and procaspases through adjacent surfaces Death-associated protein kinase: A molecule with functional antagonistic duality and a potential role in inflammatory bowel disease (Review)NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis.The Q705K polymorphism in NLRP3 is a gain-of-function alteration leading to excessive interleukin-1β and IL-18 production.Polymorphism of NLRP3 Gene and Association with Susceptibility to Digestive Disorders in Rabbit Association of EBF1, FAM167A(C8orf13)-BLK and TNFSF4 gene variants with primary Sjögren's syndrome.Innate immunity in the small intestine.The role of bacteria and pattern-recognition receptors in Crohn's disease.Common genetic variations in the NALP3 inflammasome are associated with delayed apoptosis of human neutrophils.C10X polymorphism in the CARD8 gene is associated with bacteraemia.The CARD8 p.C10X mutation associates with a low anti-glycans antibody response in patients with Crohn's disease Mitochondria-targeted antioxidant MitoQ ameliorates experimental mouse colitis by suppressing NLRP3 inflammasome-mediated inflammatory cytokines.Inflammasomes and their activation.Cytokine profile in a cohort of healthy blood donors carrying polymorphisms in genes encoding the NLRP3 inflammasome.Role of genetic alterations in the NLRP3 and CARD8 genes in health and disease.Inflammasomes and the microbiota--partners in the preservation of mucosal homeostasis.Cross talk between neuroregulatory molecule and monocyte: nerve growth factor activates the inflammasome Sporadic colorectal cancer: microbial contributors to disease prevention, development and therapy Clinical relevance of single nucleotide polymorphisms within the entire NLRP3 gene in patients with major blunt trauma.Genetic Polymorphisms in Inflammasome-Dependent Innate Immunity among Pediatric Patients with Severe Renal Parenchymal Infections.NLRP3 p.Q705K and CARD8 p.C10X single nucleotide polymorphisms are not associated with susceptibility to rheumatoid arthritis: a meta-analysis.CARD8 rs2043211 (p.C10X) polymorphism is not associated with disease susceptibility or cardiovascular events in Spanish rheumatoid arthritis patients NLRP3 Inflammasome Expression and Activation in Human Atherosclerosis.The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis.NLRP3 inflammasome has a protective effect against oxazolone-induced colitis: a possible role in ulcerative colitis.Q705K variant in NLRP3 gene confers protection against myocardial infarction in female individuals.Human gene variants linked to enhanced NLRP3 activity limit intramacrophage growth of Mycobacterium tuberculosis.The inflammasomes in health and disease: from genetics to molecular mechanisms of autoinflammation and beyond Genetic and molecular basis of inflammasome-mediated disease.Antibiotic therapy in inflammatory bowel disease: a systematic review and meta-analysis.Is metabolic stress a common denominator in inflammatory bowel disease?The role of the NLRP3 inflammasome in gout.Microparticles and their impact on intestinal immunity.Research progress on the NLRP3 inflammasome and its role in the central nervous system.Association of NLRP3 and CARD8 genetic polymorphisms with juvenile idiopathic arthritis in a Taiwanese population.Interactions between Nod-Like Receptors and Intestinal Bacteria.

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Combined polymorphisms in genes encoding the inflammasome components NALP3 and CARD8 confer susceptibility to Crohn's disease in Swedish men.

http://www.wikidata.org/entity/Q51752126

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2009 nî lūn-bûn

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Combined polymorphisms in gene ...... rohn's disease in Swedish men.

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Combined polymorphisms in gene ...... rohn's disease in Swedish men.

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Combined polymorphisms in gene ...... rohn's disease in Swedish men.

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The American Journal of Gastroenterology

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Combined polymorphisms in gene ...... Crohn's disease in Swedish men

@en

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Curt Tysk

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Deepti Verma

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Johan D Söderholm

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Jonas Halfvarsson

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Leif Törkvist

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Maria Lerm

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Mats Fredrikson

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Mikael Lördal

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Peter Söderkvist

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Urban Sjöqvist

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P2860

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

Mechanisms of Disease: pathogenesis of Crohn's disease and ulcerative colitis

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways

Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome

Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection

Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes

The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta

NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder

Molecular cloning of the interleukin-1 beta converting enzyme

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10.1038/AJG.2009.29

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