about
Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells, and C3a enhances their homing-related responses to SDF-1A novel role of complement: mice deficient in the fifth component of complement (C5) exhibit impaired liver regeneration.Synthesis, absolute configuration and antimuscarinic activity of the enantiomers of [1-(2,2-diphenyl-[1,3]dioxolan-4-yl)-ethyl]-dimethyl-amine.Cell-cycle inhibition by Helicobacter pylori L-asparaginaseExhaustive CoMFA and CoMSIA analyses around different chemical entities: a ligand-based study exploring the affinity and selectivity profiles of 5-HT1A ligands.Synthesis of 5-methyl-1,3-oxathiolane-based nucleoside analogues as potential antiviral agents.Synthesis, biological evaluation and molecular modeling of 1-oxa-4-thiaspiro- and 1,4-dithiaspiro[4.5]decane derivatives as potent and selective 5-HT1A receptor agonists.Synthesis, structural characterization and biological evaluation of 4'-C-methyl- and phenyl-dioxolane pyrimidine and purine nucleosides.1,3-Dioxolane-based ligands incorporating a lactam or imide moiety: structure-affinity/activity relationship at alpha1-adrenoceptor subtypes and at 5-HT1A receptors.Discovery of a new series of 5-HT1A receptor agonists.Design and characterization of a mutation outside the active site of human thymidylate synthase that affects ligand binding.Kinetic analysis of the interactions of complement receptor 2 (CR2, CD21) with its ligands C3d, iC3b, and the EBV glycoprotein gp350/220.C3a and C3b activation products of the third component of complement (C3) are critical for normal liver recovery after toxic injury.Synthesis and structure-activity relationships of 1-aralkyl-4-benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent sigma ligands.1,2,4-Benzothiadiazine derivatives as alpha1 and 5-HT1A receptor ligands.1,3-Dioxolane-based ligands as rigid analogues of naftopidil: structure-affinity/activity relationships at alpha1 and 5-HT1A receptors.(2,2-Diphenyl-[1,3]oxathiolan-5-ylmethyl)-(3-phenyl-propyl)-amine: a potent and selective 5-HT(1A) receptor agonist.Fluorometric detection of protein-ligand engagement: The case of phosphodiesterase5.Novel monoclonal antibodies against mouse C3 interfering with complement activation: description of fine specificity and applications to various immunoassays.Structure-Activity Relationships within a Series of σ1 and σ2 Receptor Ligands: Identification of a σ2 Receptor Agonist (BS148) with Selective Toxicity against Metastatic Melanoma.Synthesis and antimuscarinic activity of some ether- and thioether-bearing 1,3-dioxolanes and related sulfoxides and sulfones.Further insights into the pharmacology of the human trace amine-associated receptors: discovery of novel ligands for TAAR1 by a virtual screening approach.Development, validation and application of an LC-MS/MS bioanalytical method for the quantification of GF449, a novel 5-HT1A agonist, in rat plasma and brain.Scouting new sigma receptor ligands: Synthesis, pharmacological evaluation and molecular modeling of 1,3-dioxolane-based structures and derivatives.Structure-affinity/activity relationships of 1,4-dioxa-spiro[4.5]decane based ligands at α<alpha>1 and 5-HT1A receptors.Synthesis, biological evaluation, and docking studies of tetrahydrofuran- cyclopentanone- and cyclopentanol-based ligands acting at adrenergic α₁- and serotonine 5-HT1A receptors.1,3-dioxolane-based ligands as a novel class of alpha1-adrenoceptor antagonists.Diastereoselective Synthesis of (1,3-Dioxan-4-yl)pyrimidine and Purin Nucleoside AnaloguesEnantiomeric resolution of [(2,2-diphenyl-1,3-dioxolan-4-yl)methyl](2-phenoxyethyl)amine, a potent α1 and 5-HT1A receptor ligand: an in vitro and computational studySynthesis and biological evaluation of 1,3-dioxolane-based 5-HT1A receptor agonists for CNS disorders and neuropathic painA homology modelling-driven study leading to the discovery of the first mouse trace amine-associated receptor 5 (TAAR5) antagonistsA New and Versatile Synthesis of 1,3-Dioxan-5-yl-pyrimidine and Purine Nucleoside AnaloguesSynthesis of Heteroaryl ortho-Phenoxyethylamines via Suzuki Cross-Coupling: Easy Access to New Potential Scaffolds in Medicinal ChemistryTransacetalization of Acetals with Butane-1,2,4-triol Using Cobalt(II) Chloride and ChlorotrimethylsilaneSynthesis and Antimuscarinic Activity of Derivatives of 2-Substituted-1,3-DioxolanesStructure–activity relationship at α-adrenergic receptors within a series of imidazoline analogues of cirazolineMultitarget 1,4-Dioxane Compounds Combining Favorable D2-like and 5-HT1A Receptor Interactions with Potential for the Treatment of Parkinson's Disease or Schizophrenia
P50
Q28201550-F7A88FEF-ADF2-40FF-9EAF-6612BD14C0C4Q31839030-C997E227-A04C-4E84-8735-146C26402ACDQ32020805-DD9B5450-7EB8-4F46-898C-3BA4A73C2D92Q33749811-A89B823F-0F2F-4499-8D5E-C5BC971946A9Q36257797-1321554D-3CE4-4444-AB96-D9CA7E0565AAQ39323580-0DCFB4E9-BED7-412C-BB92-69E9204665E3Q39334768-029C0C3D-FF2F-43B5-B920-EBB830EBAB36Q40586859-BE40FD55-F9C2-4BDC-AF27-4FE501DDEA07Q42982831-D1CE0771-C578-4C5A-8982-15206F748C28Q43149191-6093C9D8-0F4E-4B1F-96AD-ECA9BD4171B8Q43231798-B66D3BC6-E6D8-44FE-9CDF-75540DA49265Q43683652-5C0F102D-F122-46C9-97EF-21842E3F7FC5Q44968865-0DC22EAA-B52E-4F24-AA38-FD949317B670Q45212847-F47366D0-6188-4A0A-A47F-0D86F3E229F9Q45248317-AA72770D-E5FB-4410-9288-4783714C3E43Q46157845-E7731E01-B067-4230-92E5-23D6D84233E8Q46186696-7FF937E1-6433-4630-9BC3-5275D0FB7D36Q47408791-FE8A9523-47AD-4138-B99A-06FE426235F1Q47714091-F1297FFA-1689-45FC-94D5-E18357914A46Q47756273-6AC922B0-A6BE-488F-8D20-4381121A88BFQ47779138-5D191BEE-9D9C-4F90-886D-8EC1E3FDF2FCQ48281018-95D90508-E27A-4CA0-A98A-BBA51DAA1533Q48837667-4B97746F-4652-49C7-88D4-1C06AA272F1BQ48908983-A6D1C342-FA86-4162-88FE-1CA3F08666D5Q51049557-E7AB5CEC-85CE-4560-9DAF-340FA5F2C251Q51763201-1BA21A6C-4B2B-4A6D-A53E-D545EF497E3AQ51838385-5ECF38FE-E9E2-4233-8272-1400DC8BAFA2Q56763260-346E948D-61E3-4F25-9525-5FFD435EBEABQ59275961-771C88E7-8E67-4F9B-BD4D-F5D79DFC7DB9Q62590308-E2741AB2-2800-48BB-8CE7-97C3A0D33ABDQ62590310-3634EA01-DB01-4836-B87E-E1DC48363E8BQ62590311-C2602516-4843-4A2D-A26F-590137D1E01AQ62590312-E32235C1-5B30-4429-92B9-5A7388900D8DQ62590314-A150DB13-089C-49EB-9591-4363C74D5574Q62590316-2F68A78D-1696-4719-94ED-E1EC4C45D523Q62590319-3C6EBC44-1981-49AA-9DBA-3720E61890CBQ90889342-24E487FD-B53C-458D-8B2C-5066D78C04A7
P50
description
hulumtuese
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Silvia Franchini
@ast
Silvia Franchini
@en
Silvia Franchini
@es
Silvia Franchini
@nl
Silvia Franchini
@sl
type
label
Silvia Franchini
@ast
Silvia Franchini
@en
Silvia Franchini
@es
Silvia Franchini
@nl
Silvia Franchini
@sl
prefLabel
Silvia Franchini
@ast
Silvia Franchini
@en
Silvia Franchini
@es
Silvia Franchini
@nl
Silvia Franchini
@sl
P1053
C-5733-2015
P106
P1153
6603147373
P21
P31
P3829
P496
0000-0002-6320-9712