about
Effect of trehalose on the properties of mutant {gamma}PKC, which causes spinocerebellar ataxia type 14, in neuronal cell lines and cultured Purkinje cells.Identification of a new family of spinocerebellar ataxia type 14 in the Japanese spinocerebellar ataxia population by the screening of PRKCG exon 4.Establishment of a novel fluorescence-based method to evaluate chaperone-mediated autophagy in a single neuron.A knockin mouse model of spinocerebellar ataxia type 3 exhibits prominent aggregate pathology and aberrant splicing of the disease gene transcript.JosD1, a membrane-targeted deubiquitinating enzyme, is activated by ubiquitination and regulates membrane dynamics, cell motility, and endocytosisElucidation of the molecular mechanism and exploration of novel therapeutics for spinocerebellar ataxia caused by mutant protein kinase Cγ.Deregulation of the actin cytoskeleton and macropinocytosis in response to phorbol ester by the mutant protein kinase C gamma that causes spinocerebellar ataxia type 14.Regulatory Mechanisms of Vitamin D3 on Production of Nitric Oxide and Pro-inflammatory Cytokines in Microglial BV-2 Cells.Retinoic acid receptor agonist Am80 inhibits CXCL2 production from microglial BV-2 cells via attenuation of NF-κB signaling.Insulin-like growth factor 1 specifically up-regulates expression of modifier subunit of glutamate-cysteine ligase and enhances glutathione synthesis in SH-SY5Y cells.Mutant γPKC that causes spinocerebellar ataxia type 14 upregulates Hsp70, which protects cells from the mutant's cytotoxicity.Mutant protein kinase C gamma that causes spinocerebellar ataxia type 14 (SCA14) is selectively degraded by autophagy.Effects of continuous administration of paroxetine on ligand binding site and expression of serotonin transporter protein in mouse brain.Fragmentation of protein kinase N (PKN) in the hydrocephalic rat brain.Developmental expression of GPR3 in rodent cerebellar granule neurons is associated with cell survival and protects neurons from various apoptotic stimuli.Fused protein of deltaPKC activation loop and PDK1-interacting fragment (deltaAL-PIF) functions as a pseudosubstrate and an inhibitory molecule for PDK1 when expressed in cells.Adenoviral gene transfer of aspartoacylase ameliorates tonic convulsions of spontaneously epileptic rats.Adenoviral gene transfer of aspartoacylase into the tremor rat, a genetic model of epilepsy, as a trial of gene therapy for inherited epileptic disorder.Pharmacological properties of TRK-820 on cloned mu-, delta- and kappa-opioid receptors and nociceptin receptor.Repeated administration of methamphetamine causes hypersensitivity of D2 receptor in rat ventral tegmental area.Involvement of alpha7- and alpha4beta2-type postsynaptic nicotinic acetylcholine receptors in nicotine-induced excitation of dopaminergic neurons in the substantia nigra: a patch clamp and single-cell PCR study using acutely dissociated nigral neuroPhosphorylation of PKC activation loop plays an important role in receptor-mediated translocation of PKC.Effects of the chemical chaperone 4-phenylbutylate on the function of the serotonin transporter (SERT) expressed in COS-7 cells.[Electrophysiological analysis of brain reward system in drug addiction and dependency].Cystamine-mediated inhibition of protein disulfide isomerase triggers aggregation of misfolded orexin-A in the Golgi apparatus and prevents extracellular secretion of orexin-A.A natural compound macelignan protects midbrain dopaminergic neurons from inflammatory degeneration via microglial arginase-1 expression.High fat diet induces specific pathological changes in hypothalamic orexin neurons in mice.Na(+), K(+)-ATPase dysfunction causes cerebrovascular endothelial cell degeneration in rat prefrontal cortex slice cultures.Inhibitory effects of levetiracetam on the high-voltage-activated L-type Ca²⁺ channels in hippocampal CA3 neurons of spontaneously epileptic rat (SER).Inhibition of Leukotriene B4 Action Mitigates Intracerebral Hemorrhage-Associated Pathological Events in Mice.Hypoxic stress activates chaperone-mediated autophagy and modulates neuronal cell survival.Mutant PKCγ in spinocerebellar ataxia type 14 disrupts synapse elimination and long-term depression in Purkinje cells in vivo.Extracellular ATP differentially modulates Toll-like receptor 4-mediated cell survival and death of microglia.Mitogen-activated protein kinases regulate expression of neuronal nitric oxide synthase and neurite outgrowth via non-classical retinoic acid receptor signaling in human neuroblastoma SH-SY5Y cells.Mutant gammaPKC found in spinocerebellar ataxia type 14 induces aggregate-independent maldevelopment of dendrites in primary cultured Purkinje cells.Mutant protein kinase Cgamma found in spinocerebellar ataxia type 14 is susceptible to aggregation and causes cell death.Fluorescent-based evaluation of chaperone-mediated autophagy and microautophagy activities in cultured cells.Enzymological analysis of mutant protein kinase Cgamma causing spinocerebellar ataxia type 14 and dysfunction in Ca2+ homeostasis.Axonal dysfunction in internal capsule is closely associated with early motor deficits after intracerebral hemorrhage in mice.The Toll-like receptor 4-activated neuroprotective microglia subpopulation survives via granulocyte macrophage colony-stimulating factor and JAK2/STAT5 signaling.
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P50
description
onderzoeker
@nl
researcher ORCID: 0000-0002-9894-4768
@en
name
Takahiro Seki
@ast
Takahiro Seki
@en
Takahiro Seki
@es
Takahiro Seki
@nl
Takahiro Seki
@sl
type
label
Takahiro Seki
@ast
Takahiro Seki
@en
Takahiro Seki
@es
Takahiro Seki
@nl
Takahiro Seki
@sl
prefLabel
Takahiro Seki
@ast
Takahiro Seki
@en
Takahiro Seki
@es
Takahiro Seki
@nl
Takahiro Seki
@sl
P108
P106
P1153
34572948800
P31
P4012
P496
0000-0002-9894-4768