High throughput kinetic profiling approach for covalent binding to peptides: application to skin sensitization potency of Michael acceptor electrophiles.
about
Pyridoxylamine reactivity kinetics as an amine based nucleophile for screening electrophilic dermal sensitizersRapid and simple kinetics screening assay for electrophilic dermal sensitizers using nitrobenzenethiolHaptenation: chemical reactivity and protein bindingEvaluation of the hypersensitivity potential of alternative butter flavoringsMethyl methacrylate and respiratory sensitization: a critical reviewEvaluation of a High-Throughput Peptide Reactivity Format Assay for Assessment of the Skin Sensitization Potential of ChemicalsIn vitro methods for hazard assessment of industrial chemicals - opportunities and challengesPredicting skin sensitizer potency based on in vitro data from KeratinoSens and kinetic peptide binding: global versus domain-based assessment.The Nrf2-Keap1-ARE toxicity pathway as a cellular sensor for skin sensitizers--functional relevance and a hypothesis on innate reactions to skin sensitizers.Non-animal sensitization testing: state-of-the-art.Penetration and haptenation of p-phenylenediamine.Reporter cell lines for skin sensitization testing.Non-animal assessment of skin sensitization hazard: Is an integrated testing strategy needed, and if so what should be integrated?Skin sensitizers in cosmetics and beyond: potential multiple mechanisms of action and importance of T-cell assays for in vitro screening.Bayesian integrated testing strategy to assess skin sensitization potency: from theory to practice.A dataset on 145 chemicals tested in alternative assays for skin sensitization undergoing prevalidation.Is skin penetration a determining factor in skin sensitization potential and potency? Refuting the notion of a LogKow threshold for skin sensitization.Integrated testing and assessment approaches for skin sensitization: a commentary.The selective peptide reactivity of chemical respiratory allergens under competitive and non-competitive conditions.Determination of Protein Haptenation by Chemical Sensitisers within the Complexity of the Human Skin Proteome.The definition of the applicability domain relevant to skin sensitization for the aromatic nucleophilic substitution mechanism.Antibacterial Evaluation and Virtual Screening of New Thiazolyl-Triazole Schiff Bases as Potential DNA-Gyrase Inhibitors.TIMES-SS--recent refinements resulting from an industrial skin sensitisation consortium.Development of ecotoxicity QSAR models based on partial charge descriptors for acrylate and related compounds.Predicting Michael-acceptor reactivity and toxicity through quantum chemical transition-state calculations.Consideration of reactivity to acute fish toxicity ofα,β-unsaturated carbonyl ketones and aldehydes
P2860
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P2860
High throughput kinetic profiling approach for covalent binding to peptides: application to skin sensitization potency of Michael acceptor electrophiles.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh-hant
name
High throughput kinetic profil ...... ichael acceptor electrophiles.
@en
High throughput kinetic profil ...... ichael acceptor electrophiles.
@nl
type
label
High throughput kinetic profil ...... ichael acceptor electrophiles.
@en
High throughput kinetic profil ...... ichael acceptor electrophiles.
@nl
prefLabel
High throughput kinetic profil ...... ichael acceptor electrophiles.
@en
High throughput kinetic profil ...... ichael acceptor electrophiles.
@nl
P356
P1476
High throughput kinetic profil ...... Michael acceptor electrophiles
@en
P2093
David W Roberts
P304
P356
10.1021/TX800431X
P577
2009-03-01T00:00:00Z