Nek7 kinase targeting leads to early mortality, cytokinesis disturbance and polyploidy.
about
Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5Human Nek7-interactor RGS2 is required for mitotic spindle organization.Mitotic regulation of fungal cell-to-cell connectivity through septal pores involves the NIMA kinase."Stop Ne(c)king around": How interactomics contributes to functionally characterize Nek family kinasesCharacterization of the human NEK7 interactome suggests catalytic and regulatory properties distinct from those of NEK6The histone methyltransferase Wolf-Hirschhorn syndrome candidate 1-like 1 (WHSC1L1) is involved in human carcinogenesis.KLF1-null neonates display hydrops fetalis and a deranged erythroid transcriptome.C. elegans NIMA-related kinases NEKL-2 and NEKL-3 are required for the completion of molting.Aberrant expression of maternal Plk1 and Dctn3 results in the developmental failure of human in-vivo- and in-vitro-matured oocytes.Never in mitosis gene A related kinase-6 attenuates pressure overload-induced activation of the protein kinase B pathway and cardiac hypertrophyA Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome ActivationDifferential Expression of Long Noncoding RNAs in Human Cumulus Cells Related to Embryo Developmental Potential: A Microarray Analysis.Mitotic kinase cascades orchestrating timely disjunction and movement of centrosomes maintain chromosomal stability and prevent cancer.Inactivation of max-interacting protein 1 induces renal cilia disassembly through reduction in levels of intraflagellar transport 20 in polycystic kidney.NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome componentCell cycle regulation by the NEK family of protein kinases.Mechanism and Regulation of NLRP3 Inflammasome Activation.Role of primary cilia in non-dividing and post-mitotic cells.Nek family of kinases in cell cycle, checkpoint control and cancer.The cell adhesion gene PVRL3 is associated with congenital ocular defects.NEK7 is an essential mediator of NLRP3 activation downstream of potassium effluxSomatic Mutations in NEK9 Cause Nevus Comedonicus.NEK7 is required for G1 progression and procentriole formation.DYNLL/LC8 protein controls signal transduction through the Nek9/Nek6 signaling module by regulating Nek6 binding to Nek9.The peptidyl prolyl isomerase cyclophilin A localizes at the centrosome and the midbody and is required for cytokinesis.Mitotic Regulation by NEK Kinase Networks.Conserved Ankyrin Repeat Proteins and Their NIMA Kinase Partners Regulate Extracellular Matrix Remodeling and Intracellular Trafficking in Caenorhabditis elegans.A bifurcated signaling cascade of NIMA-related kinases controls distinct kinesins in anaphase.Downregulation of NIMA-related kinase-7 inhibits cell proliferation by inducing cell cycle arrest in human retinoblastoma cells.Recessive NEK9 mutation causes a lethal skeletal dysplasia with evidence of cell cycle and ciliary defects.NEK7 regulates dendrite morphogenesis in neurons via Eg5-dependent microtubule stabilization.
P2860
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P2860
Nek7 kinase targeting leads to early mortality, cytokinesis disturbance and polyploidy.
description
2010 nî lūn-bûn
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2010年の論文
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2010年学术文章
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2010年学术文章
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2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
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2010年學術文章
@zh-hant
name
Nek7 kinase targeting leads to early mortality, cytokinesis disturbance and polyploidy.
@en
Nek7 kinase targeting leads to early mortality, cytokinesis disturbance and polyploidy.
@nl
type
label
Nek7 kinase targeting leads to early mortality, cytokinesis disturbance and polyploidy.
@en
Nek7 kinase targeting leads to early mortality, cytokinesis disturbance and polyploidy.
@nl
prefLabel
Nek7 kinase targeting leads to early mortality, cytokinesis disturbance and polyploidy.
@en
Nek7 kinase targeting leads to early mortality, cytokinesis disturbance and polyploidy.
@nl
P2093
P2860
P356
P1433
P1476
Nek7 kinase targeting leads to early mortality, cytokinesis disturbance and polyploidy
@en
P2093
P2860
P2888
P304
P356
10.1038/ONC.2010.162
P407
P577
2010-05-17T00:00:00Z