HFE modulates transferrin receptor 2 levels in hepatoma cells via interactions that differ from transferrin receptor 1-HFE interactions.
about
N-glycosylation is important for the correct intracellular localization of HFE and its ability to decrease cell surface transferrin bindingHereditary hemochromatosis in the post-HFE eraMechanisms of mammalian iron homeostasisDifferential HFE gene expression is regulated by alternative splicing in human tissuesComparison of changes in gene expression of transferrin receptor-1 and other iron-regulatory proteins in rat liver and brain during acute-phase responseStoichiometries of transferrin receptors 1 and 2 in human liverHepatocyte-targeted HFE and TFR2 control hepcidin expression in mice.Iron uptake from plasma transferrin by a transferrin receptor 2 mutant mouse model of haemochromatosis.Alternative polyadenylation and nonsense-mediated decay coordinately regulate the human HFE mRNA levels.Hepcidin induction by transgenic overexpression of Hfe does not require the Hfe cytoplasmic tail, but does require hemojuvelin.Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression.Ferristatin II promotes degradation of transferrin receptor-1 in vitro and in vivo.In situ proximity ligation assays indicate that hemochromatosis proteins Hfe and transferrin receptor 2 (Tfr2) do not interact.Hereditary hemochromatosis and transferrin receptor 2BMP6 treatment compensates for the molecular defect and ameliorates hemochromatosis in Hfe knockout mice.The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression.Iron refractory iron deficiency anemiaIron homeostasis: recently identified proteins provide insight into novel control mechanismsTransforming Growth Factor β1 (TGF-β1) Activates Hepcidin mRNA Expression in HepatocytesThe global burden of iron overload.Bone morphogenetic protein signaling is impaired in an HFE knockout mouse model of hemochromatosis.The liver: conductor of systemic iron balance.Molecular mechanisms of normal iron homeostasis.Molecular basis of hereditary iron homeostasis defects.Molecular diagnostic and pathogenesis of hereditary hemochromatosis.The role of hepatic transferrin receptor 2 in the regulation of iron homeostasis in the body.The liver in regulation of iron homeostasis.Effect of HFE variants on sphingolipid expression by SH-SY5Y human neuroblastoma cells.The role of transferrin receptor 1 and 2 in transferrin-bound iron uptake in human hepatoma cells.Glu(332) in the Nicastrin ectodomain is essential for gamma-secretase complex maturation but not for its activity.Function of the hemochromatosis protein HFE: Lessons from animal models.Genome-wide association study of concentrations of iron and other minerals in longissimus muscle of Angus cattle.The Transferrin Receptors, TfR1 and TfR2, Bind Transferrin through Differing Mechanisms.DNA methylation of hepatic iron sensing genes and the regulation of hepcidin expression.
P2860
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P2860
HFE modulates transferrin receptor 2 levels in hepatoma cells via interactions that differ from transferrin receptor 1-HFE interactions.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh-hant
name
HFE modulates transferrin rece ...... n receptor 1-HFE interactions.
@en
HFE modulates transferrin rece ...... n receptor 1-HFE interactions.
@nl
type
label
HFE modulates transferrin rece ...... n receptor 1-HFE interactions.
@en
HFE modulates transferrin rece ...... n receptor 1-HFE interactions.
@nl
prefLabel
HFE modulates transferrin rece ...... n receptor 1-HFE interactions.
@en
HFE modulates transferrin rece ...... n receptor 1-HFE interactions.
@nl
P2093
P2860
P356
P1476
HFE modulates transferrin rece ...... n receptor 1-HFE interactions.
@en
P2093
Caroline A Enns
Junwei Gao
Juxing Chen
Maja Chloupková
Tara L Chapman-Arvedson
P2860
P304
36862-36870
P356
10.1074/JBC.M706720200
P407
P577
2007-10-23T00:00:00Z