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Elevated paternal glucocorticoid exposure alters the small noncoding RNA profile in sperm and modifies anxiety and depressive phenotypes in the offspring.Wheel running and environmental enrichment differentially modify exon-specific BDNF expression in the hippocampus of wild-type and pre-motor symptomatic male and female Huntington's disease mice.Is Dysregulation of the HPA-Axis a Core Pathophysiology Mediating Co-Morbid Depression in Neurodegenerative Diseases?Treatment of depressive-like behaviour in Huntington's disease mice by chronic sertraline and exercise.Dissociating the therapeutic effects of environmental enrichment and exercise in a mouse model of anxiety with cognitive impairment.A Tale of Two Maladies? Pathogenesis of Depression with and without the Huntington's Disease Gene Mutation.Positive environmental modification of depressive phenotype and abnormal hypothalamic-pituitary-adrenal axis activity in female C57BL/6J mice during abstinence from chronic ethanol consumptionVascular endothelial growth factor and brain-derived neurotrophic factor in quetiapine treated first-episode psychosis.Effects of environmental manipulations in genetically targeted animal models of affective disorders.Localized changes to glycogen synthase kinase-3 and collapsin response mediator protein-2 in the Huntington's disease affected brain.Exercise alters mouse sperm small noncoding RNAs and induces a transgenerational modification of male offspring conditioned fear and anxiety.Differential effects of early environmental enrichment on emotionality related behaviours in Huntington's disease transgenic mice.Cortisol and depression in pre-diagnosed and early stage Huntington's disease.Loss of the Sexually Dimorphic Neuro-Inflammatory Response in a Transgenic Mouse Model of Huntington's Disease.Short-term memory acquisition in female Huntington's disease mice is vulnerable to acute stress.Tissue-type plasminogen activator is an extracellular mediator of Purkinje cell damage and altered gait.N-acetylcysteine modulates glutamatergic dysfunction and depressive behavior in Huntington's disease.Deficits in experience-dependent cortical plasticity and sensory-discrimination learning in presymptomatic Huntington's disease mice.High stress hormone levels accelerate the onset of memory deficits in male Huntington's disease mice.Differential effects of voluntary physical exercise on behavioral and brain-derived neurotrophic factor expression deficits in Huntington's disease transgenic mice.The influence of the HPG axis on stress response and depressive-like behaviour in a transgenic mouse model of Huntington's disease.Elevated paternal glucocorticoid exposure modifies memory retention in female offspring.Paternal environmental enrichment transgenerationally alters affective behavioral and neuroendocrine phenotypes.Depression-related behaviours displayed by female C57BL/6J mice during abstinence from chronic ethanol consumption are rescued by wheel-running.Transgenerational paternal transmission of acquired traits: Stress-induced modification of the sperm regulatory transcriptome and offspring phenotypes.Novel approaches to alcohol rehabilitation: Modification of stress-responsive brain regions through environmental enrichment.Adolescent inhalant abuse results in adrenal dysfunction and a hypermetabolic phenotype with persistent growth impairmentsHypersensitivity to sertraline in the absence of hippocampal 5-HT1AR and 5-HTT gene expression changes following paternal corticosterone treatmentHPA axis regulation and stress response is subject to intergenerational modification by paternal trauma and stressEnvironmental enrichment rescues female-specific hyperactivity of the hypothalamic-pituitary-adrenal axis in a model of Huntington's disease
P50
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P50
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wetenschapper
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հետազոտող
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Terence Y Pang
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Terence Y Pang
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Terence Y Pang
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Terence Y Pang
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Terence Y Pang
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Terence Y Pang
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Terence Y Pang
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Terence Y Pang
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Terence Y Pang
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Terence Y Pang
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Terence Y Pang
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Terence Y Pang
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Terence Y Pang
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Terence Y Pang
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Terence Y Pang
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P106
P31
P496
0000-0002-7000-5304