Role of the catalytic serine in the interactions of serine proteinases with protein inhibitors of the serpin family. Contribution of a covalent interaction to the binding energy of serpin-proteinase complexes.
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Pepsin-inhibitory activity of the uterine serpinsNeuroserpin Differentiates Between Forms of Tissue Type Plasminogen Activator via pH Dependent Deacylation.Neuroserpin, a brain-associated inhibitor of tissue plasminogen activator is localized primarily in neurons. Implications for the regulation of motor learning and neuronal survivalPolypeptide binding proteins: what remains to be discovered?Formation of the covalent chymotrypsin.antichymotrypsin complex involves no large-scale movement of the enzyme.Partitioning of serpin-proteinase reactions between stable inhibition and substrate cleavage is regulated by the rate of serpin reactive center loop insertion into beta-sheet A.A urokinase-type plasminogen activator-inhibiting cyclic peptide with an unusual P2 residue and an extended protease binding surface demonstrates new modalities for enzyme inhibition.Identification of centerin: a novel human germinal center B cell-restricted serpin.Identification of factor Xa residues critical for interaction with protein Z-dependent protease inhibitor: both active site and exosite interactions are required for inhibition.Activation of Snake in a serine protease cascade that defines the dorsoventral axis is atypical and pipe-independent in Drosophila embryosSpecificity and selectivity profile of EP217609: a new neutralizable dual-action anticoagulant that targets thrombin and factor XaMajor proteinase movement upon stable serpin-proteinase complex formationFunctional diversity of secreted cestode Kunitz proteins: Inhibition of serine peptidases and blockade of cation channels.Distinguishing the specificities of closely related proteases. Role of P3 in substrate and inhibitor discrimination between tissue-type plasminogen activator and urokinase.Kinetic intermediates en route to the final serpin-protease complex: studies of complexes of α1-protease inhibitor with trypsinRole of P2 glycine in determining the specificity of antithrombin reaction with coagulation proteases.Serpins, immunity and autoimmunity: old molecules, new functions.Engineering functional antithrombin exosites in alpha1-proteinase inhibitor that specifically promote the inhibition of factor Xa and factor IXa.Inactivation of papain by antithrombin due to autolytic digestion: a model of serpin inactivation of cysteine proteinases.The serpin inhibitory mechanism is critically dependent on the length of the reactive center loop.The pH dependence of serpin-proteinase complex dissociation reveals a mechanism of complex stabilization involving inactive and active conformational states of the proteinase which are perturbable by calcium.alpha1-Proteinase inhibitor forms initial non-covalent and final covalent complexes with elastase analogously to other serpin-proteinase pairs, suggesting a common mechanism of inhibition.Antithrombin-mediated anticoagulant activity of sulfated polysaccharides: different mechanisms for heparin and sulfated galactans.Optimal subsite occupancy and design of a selective inhibitor of urokinase.Stable complex formation between serine protease inhibitor and zymogen: coagulation factor X cleaves the Arg393-Ser394 bond in a reactive centre loop of antithrombin in the presence of heparin.
P2860
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P2860
Role of the catalytic serine in the interactions of serine proteinases with protein inhibitors of the serpin family. Contribution of a covalent interaction to the binding energy of serpin-proteinase complexes.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh-hant
name
Role of the catalytic serine i ...... f serpin-proteinase complexes.
@en
Role of the catalytic serine i ...... f serpin-proteinase complexes.
@nl
type
label
Role of the catalytic serine i ...... f serpin-proteinase complexes.
@en
Role of the catalytic serine i ...... f serpin-proteinase complexes.
@nl
prefLabel
Role of the catalytic serine i ...... f serpin-proteinase complexes.
@en
Role of the catalytic serine i ...... f serpin-proteinase complexes.
@nl
P2093
P356
P1476
Role of the catalytic serine i ...... f serpin-proteinase complexes.
@en
P2093
Ginsburg D
Kvassman J
Lawrence DA
P304
30007-30017
P356
10.1074/JBC.270.50.30007
P407
P577
1995-12-01T00:00:00Z