2-Amino-3-(methylamino)-propanoic acid (BMAA) in cycad flour: an unlikely cause of amyotrophic lateral sclerosis and parkinsonism-dementia of Guam.
about
The emerging science of BMAA: do cyanobacteria contribute to neurodegenerative disease?Amyotrophic lateral sclerosis and environmental factorsDiverse taxa of cyanobacteria produce beta-N-methylamino-L-alanine, a neurotoxic amino acidThe complex molecular biology of amyotrophic lateral sclerosis (ALS)Beta-N-methylamino-L-alanine enhances neurotoxicity through multiple mechanismsA mechanism for slow release of biomagnified cyanobacterial neurotoxins and neurodegenerative disease in GuamSearching for a link between the L-BMAA neurotoxin and amyotrophic lateral sclerosis: a study protocol of the French BMAALS programmeConservation Implications of Chamorro Consumption of Flying Foxes as a Possible Cause of Amyotrophic Lateral Sclerosis-Parkinsonism Dementia Complex in GuamDamage and repair of nerve cell DNA in toxic stress.Hippocampal and entorhinal cortex neurofibrillary tangle formation in Guamanian Chamorros free of overt neurologic dysfunction.On the decline and etiology of high-incidence motor system disease in West Papua (southwest New Guinea).Parkinson-dementia complex and development of a new stable isotope dilution assay for BMAA detection in tissueAdult onset motor neuron disease: worldwide mortality, incidence and distribution since 1950.Motor neuron disease.Transfer of a cyanobacterial neurotoxin within a temperate aquatic ecosystem suggests pathways for human exposureBiomagnification of cyanobacterial neurotoxins and neurodegenerative disease among the Chamorro people of GuamReturn of the cycad hypothesis - does the amyotrophic lateral sclerosis/parkinsonism dementia complex (ALS/PDC) of Guam have new implications for global health?Beyond Guam: the cyanobacteria/BMAA hypothesis of the cause of ALS and other neurodegenerative diseases.BMAA--an unusual cyanobacterial neurotoxin.A comparative study on three analytical methods for the determination of the neurotoxin BMAA in cyanobacteriaDiatoms: a novel source for the neurotoxin BMAA in aquatic environments.beta-Methylamino-L-alanine (BMAA) and amyotrophic lateral sclerosis-parkinsonism dementia of the western Pacific.Excitotoxicity and amyotrophic lateral sclerosis.Neurodegenerative diseases: neurotoxins as sufficient etiologic agents?β-methylamino-L-alanine (BMAA) is not found in the brains of patients with confirmed Alzheimer's diseaseDoes α-amino-β-methylaminopropionic acid (BMAA) play a role in neurodegeneration?Good mass spectrometry and its place in good science.Cyanobacterial toxins: biosynthetic routes and evolutionary roots.A critical review of the postulated role of the non-essential amino acid, β-N-methylamino-L-alanine, in neurodegenerative disease in humans.Overview of the potent cyanobacterial neurotoxin β-methylamino-L-alanine (BMAA) and its analytical determination.L-BMAA induced ER stress and enhanced caspase 12 cleavage in human neuroblastoma SH-SY5Y cells at low nonexcitotoxic concentrations.The role of excitatory amino acids in experimental models of Parkinson's disease.Glutamate, excitotoxicity and amyotrophic lateral sclerosis.Intrathecal infusion of BMAA induces selective motor neuron damage and astrogliosis in the ventral horn of the spinal cord.Development and application of a comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry method for the analysis of L-beta-methylamino-alanine in human tissue.Previous studies underestimate BMAA concentrations in cycad flour.Three phases of research on beta-N-methylamino-L-alanine (BMAA)--a neurotoxic amino acid.The discovery of BMAA, and examples of biomagnification and protein incorporation involving other non-protein amino acids.Facilitated transport of the neurotoxin, beta-N-methylamino-L-alanine, across the blood-brain barrier.Isolation of various forms of sterol beta-D-glucoside from the seed of Cycas circinalis: neurotoxicity and implications for ALS-parkinsonism dementia complex.
P2860
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P2860
2-Amino-3-(methylamino)-propanoic acid (BMAA) in cycad flour: an unlikely cause of amyotrophic lateral sclerosis and parkinsonism-dementia of Guam.
description
1990 nî lūn-bûn
@nan
1990年の論文
@ja
1990年学术文章
@wuu
1990年学术文章
@zh
1990年学术文章
@zh-cn
1990年学术文章
@zh-hans
1990年学术文章
@zh-my
1990年学术文章
@zh-sg
1990年學術文章
@yue
1990年學術文章
@zh-hant
name
2-Amino-3-
@nl
2-Amino-3-(methylamino)-propan ...... parkinsonism-dementia of Guam.
@en
type
label
2-Amino-3-
@nl
2-Amino-3-(methylamino)-propan ...... parkinsonism-dementia of Guam.
@en
prefLabel
2-Amino-3-
@nl
2-Amino-3-(methylamino)-propan ...... parkinsonism-dementia of Guam.
@en
P2093
P921
P356
P1433
P1476
2-Amino-3-(methylamino)-propan ...... parkinsonism-dementia of Guam.
@en
P2093
P304
P356
10.1212/WNL.40.5.767
P407
P577
1990-05-01T00:00:00Z