Structural determinants of the ligand-binding site of the human retinoic acid receptor alpha.
about
Retinoic acid receptors inhibit AP1 activation by regulating extracellular signal-regulated kinase and CBP recruitment to an AP1-responsive promoter.Selective alteration of gene expression in response to natural and synthetic retinoidsThe proliferating cell nuclear antigen regulates retinoic acid receptor transcriptional activity through direct protein-protein interaction.Allosteric regulation of the discriminative responsiveness of retinoic acid receptor to natural and synthetic ligands by retinoid X receptor and DNA.Chromosomal integration of retinoic acid response elements prevents cooperative transcriptional activation by retinoic acid receptor and retinoid X receptor.Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gammaMutational analysis reveals that all-trans-retinoic acid, 9-cis-retinoic acid, and antagonist interact with distinct binding determinants of RARalpha.Analysis of the ligand-binding domain of human retinoic acid receptor alpha by site-directed mutagenesis.Modular structure of glucocorticoid receptor domains is not equivalent to functional independence. Stability and activity of the steroid binding domain are controlled by sequences in separate domains.Retinoid X receptor alpha (RXRalpha) helix 12 plays an inhibitory role in the recruitment of the p160 co-activators by unliganded RXRalpha/retinoic acid receptor alpha heterodimers.
P2860
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P2860
Structural determinants of the ligand-binding site of the human retinoic acid receptor alpha.
description
1995 nî lūn-bûn
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1995年の論文
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1995年学术文章
@wuu
1995年学术文章
@zh
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
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@yue
1995年學術文章
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name
Structural determinants of the ...... retinoic acid receptor alpha.
@en
Structural determinants of the ...... retinoic acid receptor alpha.
@nl
type
label
Structural determinants of the ...... retinoic acid receptor alpha.
@en
Structural determinants of the ...... retinoic acid receptor alpha.
@nl
prefLabel
Structural determinants of the ...... retinoic acid receptor alpha.
@en
Structural determinants of the ...... retinoic acid receptor alpha.
@nl
P2093
P356
P1433
P1476
Structural determinants of the ...... retinoic acid receptor alpha.
@en
P2093
B Lefebvre
P Formstecher
P Lefebvre
P304
P356
10.1021/BI00016A019
P407
P577
1995-04-01T00:00:00Z