Two distinct heterotypic channels mediate gap junction coupling between astrocyte and oligodendrocyte connexins.
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Gap junctions couple astrocytes and oligodendrocytesHereditary spastic paraplegia is a novel phenotype for GJA12/GJC2 mutationsGap junctions in inherited human disorders of the central nervous system.Transplantation of stem cell-derived astrocytes for the treatment of amyotrophic lateral sclerosis and spinal cord injuryGap junctions and hemichannels composed of connexins: potential therapeutic targets for neurodegenerative diseasesSystemic inflammation disrupts oligodendrocyte gap junctions and induces ER stress in a model of CNS manifestations of X-linked Charcot-Marie-Tooth disease.Opalin, a transmembrane sialylglycoprotein located in the central nervous system myelin paranodal loop membraneCx32 and Cx47 mediate oligodendrocyte:astrocyte and oligodendrocyte:oligodendrocyte gap junction coupling.Connexin26 expression in brain parenchymal cells demonstrated by targeted connexin ablation in transgenic mice.Molecular disruptions of the panglial syncytium block potassium siphoning and axonal saltatory conduction: pertinence to neuromyelitis optica and other demyelinating diseases of the central nervous system.Connexin32 mutations cause loss of function in Schwann cells and oligodendrocytes leading to PNS and CNS myelination defectsAblation of Cx47 in transgenic mice leads to the loss of MUPP1, ZONAB and multiple connexins at oligodendrocyte-astrocyte gap junctionsThe extracellular matrix controls gap junction protein expression and function in postnatal hippocampal neural progenitor cellsWhite matter astrocytes in health and disease.Molecular and functional asymmetry at a vertebrate electrical synapseHeterogeneity in oligodendroglia: Is it relevant to mouse models and human disease?Pathologic and phenotypic alterations in a mouse expressing a connexin47 missense mutation that causes Pelizaeus-Merzbacher-like disease in humans.Early disruption of glial communication via connexin gap junction in multiple sclerosis, Baló's disease and neuromyelitis optica.Correlations of differentially expressed gap junction connexins Cx26, Cx30, Cx32, Cx43 and Cx46 with breast cancer progression and prognosis.Deletion of oligodendrocyte Cx32 and astrocyte Cx43 causes white matter vacuolation, astrocyte loss and early mortality.A new mutation in GJC2 associated with subclinical leukodystrophy.Cx50 requires an intact PDZ-binding motif and ZO-1 for the formation of functional intercellular channels.Gap junction communication in myelinating gliaAstrocytes are an early target in osmotic demyelination syndromeConnexins and pannexins in neuronal development and adult neurogenesisDemyelination as a rational therapeutic target for ischemic or traumatic brain injury.Characterization of Panglial Gap Junction Networks in the Thalamus, Neocortex, and Hippocampus Reveals a Unique Population of Glial Cells.Connexin composition in apposed gap junction hemiplaques revealed by matched double-replica freeze-fracture replica immunogold labelingMammalian-Specific Central Myelin Protein Opalin Is Redundant for Normal Myelination: Structural and Behavioral AssessmentsFunctional requirement for a highly conserved charged residue at position 75 in the gap junction protein connexin 32.Connexin 47 mutations increase risk for secondary lymphedema following breast cancer treatmentNeurological manifestations of oculodentodigital dysplasia: a Cx43 channelopathy of the central nervous system?Modulation of brain hemichannels and gap junction channels by pro-inflammatory agents and their possible role in neurodegenerationDeletion of astrocyte connexins 43 and 30 leads to a dysmyelinating phenotype and hippocampal CA1 vacuolation.A dominant connexin43 mutant does not have dominant effects on gap junction coupling in astrocytes.Loss of Coupling Distinguishes GJB1 Mutations Associated with CNS Manifestations of CMT1X from Those Without CNS Manifestations.Astrocyte dysfunction in temporal lobe epilepsy: K+ channels and gap junction coupling.Oligodendroglia: metabolic supporters of axons.Extracellular domains play different roles in gap junction formation and docking compatibility.Mix and match: investigating heteromeric and heterotypic gap junction channels in model systems and native tissues.
P2860
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P2860
Two distinct heterotypic channels mediate gap junction coupling between astrocyte and oligodendrocyte connexins.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh-hant
name
Two distinct heterotypic chann ...... and oligodendrocyte connexins.
@en
Two distinct heterotypic chann ...... and oligodendrocyte connexins.
@nl
type
label
Two distinct heterotypic chann ...... and oligodendrocyte connexins.
@en
Two distinct heterotypic chann ...... and oligodendrocyte connexins.
@nl
prefLabel
Two distinct heterotypic chann ...... and oligodendrocyte connexins.
@en
Two distinct heterotypic chann ...... and oligodendrocyte connexins.
@nl
P2093
P1476
Two distinct heterotypic chann ...... and oligodendrocyte connexins
@en
P2093
Charles K Abrams
Esther Fischer
Jennifer L Orthmann-Murphy
Mona Freidin
Steven S Scherer
P304
13949-13957
P356
10.1523/JNEUROSCI.3395-07.2007
P407
P577
2007-12-01T00:00:00Z