Hypoxia-inducible factors 1alpha and 2alpha exert both distinct and overlapping functions in long bone development. - Wikidata - wikimedia - TriplyDB

Hypoxia-inducible factors 1alpha and 2alpha exert both distinct and overlapping functions in long bone development.

Hypoxia-inducible factors 1alpha and 2alpha exert both distinct and overlapping functions in long bone development.

http://www.wikidata.org/entity/Q52596786

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Hypoxia-inducible factor-1α protein negatively regulates load-induced bone formation A central role for hypoxic signaling in cartilage, bone, and hematopoiesis.Detection of hypoxia inducible factors and angiogenic growth factors during foetal endochondral and intramembranous ossification.Up-regulation of glycolytic metabolism is required for HIF1α-driven bone formation Differential roles of hypoxia inducible factor subunits in multipotential stromal cells under hypoxic condition Hypoxia-inducible factor regulates osteoclast-mediated bone resorption: role of angiopoietin-like 4 Hypoxia promotes osteogenesis but suppresses adipogenesis of human mesenchymal stromal cells in a hypoxia-inducible factor-1 dependent manner Hypoxia inhibits hypertrophic differentiation and endochondral ossification in explanted tibiae.HIF-1α transgenic bone marrow cells can promote tissue repair in cases of corticosteroid-induced osteonecrosis of the femoral head in rabbits.HIF-1α regulates bone formation after osteogenic mechanical loading.Synergistic inhibition of endochondral bone formation by silencing Hif1α and Runx2 in trauma-induced heterotopic ossification.Oxygen-sensing PHDs regulate bone homeostasis through the modulation of osteoprotegerin.Hypoxia-inducible factor-1α restricts the anabolic actions of parathyroid hormone.Parathyroid hormone regulation of hypoxia-inducible factor signaling in osteoblastic cells.Conditional Deletion of Prolyl Hydroxylase Domain-Containing Protein 2 (Phd2) Gene Reveals Its Essential Role in Chondrocyte Function and Endochondral Bone Formation.Differential fracture healing resulting from fixation stiffness variability: a mouse model Constitutive stabilization of hypoxia-inducible factor alpha selectively promotes the self-renewal of mesenchymal progenitors and maintains mesenchymal stromal cells in an undifferentiated state Dimethyloxaloylglycine increases the bone healing capacity of adipose-derived stem cells by promoting osteogenic differentiation and angiogenic potential.Hypoxia-driven pathways in bone development, regeneration and disease.Passing the baton: the HIF switch.Osteoblast recruitment to sites of bone formation in skeletal development, homeostasis, and regeneration.Hypoxia signalling manipulation for bone regeneration.Hypoxia-inducible factor 1-alpha does not regulate osteoclastogenesis but enhances bone resorption activity via prolyl-4-hydroxylase 2.Hypoxia mimetic deferoxamine influences the expression of histone acetylation- and DNA methylation-associated genes in osteoblasts.Oxygen-induced transcriptional dynamics in human osteoblasts are most prominent at the onset of mineralization.Hypoxia, HIFs and bone development.MicroRNA-433 Dampens Glucocorticoid Receptor Signaling, Impacting Circadian Rhythm and Osteoblastic Gene Expression.Regulation of Osteogenic Differentiation of Placental-Derived Mesenchymal Stem Cells by Insulin-Like Growth Factors and Low Oxygen Tension.Conditional disruption of the prolyl hydroxylase domain-containing protein 2 (Phd2) gene defines its key role in skeletal development.HIF signaling in osteoblast-lineage cells promotes systemic breast cancer growth and metastasis in mice.Physiological oxygen tension modulates soluble growth factor profile after crosstalk between chondrocytes and osteoblasts.In vitro study of enhanced osteogenesis induced by HIF-1α-transduced bone marrow stem cells.HIF-2 Inhibition Supresses Inflammatory Responses and Osteoclastic Differentiation in Human Periodontal Ligament Cells.Vascular endothelial growth factors signalling in normal human dental pulp: a study of gene and protein expression.Role of the Bone Microenvironment in the Development of Painful Complications of Skeletal Metastases.Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin.

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P2860

Hypoxia-inducible factors 1alpha and 2alpha exert both distinct and overlapping functions in long bone development.

http://www.wikidata.org/entity/Q52596786

description

2010 nî lūn-bûn

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2010年の論文

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年學術文章

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2010年學術文章

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name

Hypoxia-inducible factors 1alp ...... ions in long bone development.

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Hypoxia-inducible factors 1alp ...... ions in long bone development.

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type

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Hypoxia-inducible factors 1alp ...... ions in long bone development.

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Hypoxia-inducible factors 1alp ...... ions in long bone development.

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Hypoxia-inducible factors 1alp ...... ions in long bone development.

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Hypoxia-inducible factors 1alp ...... ions in long bone development.

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P1433

Journal of Cellular Biochemistry

P1476

Hypoxia-inducible factors 1alp ...... ions in long bone development.

@en

P2093

Chao Wan

http://www.w3.org/2001/XMLSchema#string

Marie-Claude Faugere

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Ryan C Riddle

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Stacy H Shomento

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Thomas L Clemens

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Xuemei Cao

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P2860

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

A conserved family of prolyl-4-hydroxylases that modify HIF

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

Understanding the Warburg effect: the metabolic requirements of cell proliferation

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

Signal transduction to hypoxia-inducible factor 1

Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

The human hypoxia-inducible factor 1alpha gene: HIF1A structure and evolutionary conservation

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196-204

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10.1002/JCB.22396

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1

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109

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Mary L Bouxsein

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2010-01-01T00:00:00Z

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38075994

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19899108

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