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Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAsInflammatory monocytes are potent antitumor effectors controlled by regulatory CD4+ T cells.IL-2 and IL-7 determine the homeostatic balance between the regulatory and conventional CD4+ T cell compartments during peripheral T cell reconstitution.FOXO1 opposition of CD8+ T cell effector programming confers early memory properties and phenotypic diversity.TCR signaling events are required for maintaining CD4 regulatory T cell numbers and suppressive capacities in the periphery.Continuous activity of Foxo1 is required to prevent anergy and maintain the memory state of CD8+ T cells.Highly self-reactive naive CD4 T cells are prone to differentiate into regulatory T cells.Profiling the lymphoid-resident T cell pool reveals modulation by age and microbiota.Foxp3-independent loss of regulatory CD4+ T-cell suppressive capacities induced by self-deprivation.
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description
hulumtues
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researcher
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wetenschapper
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հետազոտող
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name
Arnaud Delpoux
@ast
Arnaud Delpoux
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Arnaud Delpoux
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Arnaud Delpoux
@nl
Arnaud Delpoux
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type
label
Arnaud Delpoux
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Arnaud Delpoux
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Arnaud Delpoux
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Arnaud Delpoux
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Arnaud Delpoux
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prefLabel
Arnaud Delpoux
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Arnaud Delpoux
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Arnaud Delpoux
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Arnaud Delpoux
@nl
Arnaud Delpoux
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P21
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0000-0003-4963-9676