about
In vitro and in vivo investigation of the efficacy of arylimidamide DB1831 and its mesylated salt form--DB1965--against Trypanosoma cruzi infectionTargeting the DNA-binding activity of the human ERG transcription factor using new heterocyclic dithiophene diamidinesPhenotypic evaluation and in silico ADMET properties of novel arylimidamides in acute mouse models of Trypanosoma cruzi infection.Induced topological changes in DNA complexes: influence of DNA sequences and small molecule structures.The trypanocidal activity of amidine compounds does not correlate with their binding affinity to Trypanosoma cruzi kinetoplast DNAResolution of mixed site DNA complexes with dimer-forming minor-groove binders by using electrospray ionization mass spectrometry: compound structure and DNA sequence effects.Evaluation of arylimidamides DB1955 and DB1960 as candidates against visceral leishmaniasis and Chagas' disease: in vivo efficacy, acute toxicity, pharmacokinetics, and toxicology studiesSystematic synthetic and biophysical development of mixed sequence DNA binding agents.4-Dimethyl-amino-1-(4-meth-oxy-phen-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrole-3-carbonitrile.Phenotypic Screening In Vitro of Novel Aromatic Amidines against Trypanosoma cruzi.Heterocyclic dications as a new class of telomeric G-quadruplex targeting agentsStructure-dependent inhibition of the ETS-family transcription factor PU.1 by novel heterocyclic diamidines.Water-mediated binding of agents that target the DNA minor groove.SUZUKI-MIYAURA COUPLING REACTIONS OF 3,5-DICHLORO-1,2,4-THIADIAZOLE.The unusual monomer recognition of guanine-containing mixed sequence DNA by a dithiophene heterocyclic diamidine.Synthesis and pharmacological evaluation of mono-arylimidamides as antileishmanial agentsExploration of DAPI analogues: Synthesis, antitrypanosomal activity, DNA binding and fluorescence properties.Synthesis, DNA binding and antitrypanosomal activity of benzimidazole analogues of DAPI.In vitro investigation of the efficacy of novel diamidines against Trypanosoma cruzi.Synthesis, DNA binding and antileishmanial activity of low molecular weight bis-arylimidamides.Synthesis and antiprotozoal activity of 2,5-bis[amidinoaryl]thiazoles.Synthesis, molecular modeling and anticancer activity of new coumarin containing compounds.DNA minor groove induced dimerization of heterocyclic cations: compound structure, binding affinity, and specificity for a TTAA site.Structure-dependent binding of arylimidamides to the DNA minor groove.Bichalcophenes: A Concise Synthesis of Formyl Ester- and Cyano Ester-Substituted Bithiophenes, Bifurans, and Furanothiophenes.The Thiophene "Sigma-Hole" as a Concept for Preorganized, Specific Recognition of G⋅C Base Pairs in the DNA Minor Groove.Pharmacologic efficacy of PU.1 inhibition by heterocyclic dications: a mechanistic analysis.Exploration of larger central ring linkers in furamidine analogues: synthesis and evaluation of their DNA binding, antiparasitic and fluorescence properties.Synthesis, DNA binding, fluorescence measurements and antiparasitic activity of DAPI related diamidines.Indole and Benzimidazole Bichalcophenes: Synthesis, DNA Binding and Antiparasitic Activity.A modular design for minor groove binding and recognition of mixed base pair sequences of DNA.Investigation of the electrostatic and hydration properties of DNA minor groove-binding by a heterocyclic diamidine by osmotic pressure.Antileishmanial bis-arylimidamides: DB766 analogs modified in the linker region and bis-arylimidamide structure-activity relationships.Dynamic self-assembly of DNA minor groove-binding ligand DB921 into nanotubes triggered by an alkali halide.The efficacy of novel arylimidamides against Trypanosoma cruzi in vitroSmall Sequence-Sensitive Compounds for Specific Recognition of the G⋅C Base Pair in DNA Minor Groove
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Abdelbasset A Farahat
@nl
Abdelbasset A Farahat
@sl
Abdelbasset A. Farahat
@en
Abdelbasset A. Farahat
@es
type
label
Abdelbasset A Farahat
@nl
Abdelbasset A Farahat
@sl
Abdelbasset A. Farahat
@en
Abdelbasset A. Farahat
@es
prefLabel
Abdelbasset A Farahat
@nl
Abdelbasset A Farahat
@sl
Abdelbasset A. Farahat
@en
Abdelbasset A. Farahat
@es
P106
P1153
7003423146
P31
P496
0000-0003-0664-5670