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Protein degradation pathways in Parkinson's disease: curse or blessingNaturally Occurring Isothiocyanates Exert Anticancer Effects by Inhibiting Deubiquitinating EnzymesThe requirement for Cdc48/p97 in nuclear protein quality control degradation depends on the substrate and correlates with substrate insolubilityRegulation of proteasome activity in health and diseaseThe ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solutionThe biology of proteostasis in aging and disease.Long non-coding RNA and alternative splicing modulations in Parkinson's leukocytes identified by RNA sequencing.The E3 ubiquitin ligase parkin is recruited to the 26 S proteasome via the proteasomal ubiquitin receptor Rpn13Nigral overexpression of alpha-synuclein in the absence of parkin enhances alpha-synuclein phosphorylation but does not modulate dopaminergic neurodegeneration.Identification and proteomic analysis of distinct UBE3A/E6AP protein complexes.Involvement of inhibitory PAS domain protein in neuronal cell death in Parkinson's disease.Precise assembly and regulation of 26S proteasome and correlation between proteasome dysfunction and neurodegenerative diseases.Cross-functional E3 ligases Parkin and C-terminus Hsp70-interacting protein in neurodegenerative disorders.Role of protein misfolding and proteostasis deficiency in protein misfolding diseases and aging.Policing Parkin with a UblD.Parkin Overexpression Ameliorates PrP106-126-Induced Neurotoxicity via Enhanced Autophagy in N2a Cells.Dyrk1A phosphorylates parkin at Ser-131 and negatively regulates its ubiquitin E3 ligase activity.UPS Activation in the Battle Against Aging and Aggregation-Related Diseases: An Extended Review.Mutant Twinkle increases dopaminergic neurodegeneration, mtDNA deletions and modulates Parkin expressionHuman Telomerase Reverse Transcriptase (hTERT) Positively Regulates 26S Proteasome Activity.NADH binds and stabilizes the 26S proteasomes independent of ATP.Long-term overexpression of human wild-type and T240R mutant Parkin in rat substantia nigra induces progressive dopaminergic neurodegeneration.Impact of autosomal recessive juvenile Parkinson's disease mutations on the structure and interactions of the parkin ubiquitin-like domain.Protein ingestion preserves proteasome activity during intense aseptic inflammation and facilitates skeletal muscle recovery in humans.Mechanistic contributions of FBXO7 to Parkinson disease.Modulation of ARTS and XIAP by Parkin Is Associated with Carnosic Acid Protects SH-SY5Y Cells against 6-Hydroxydopamine-Induced Apoptosis.High frequency of Parkin exon rearrangements in Mexican-mestizo patients with early-onset Parkinson's disease.Amyloid-β Increases Activity of Proteasomes Capped with 19S and 11S Regulators.
P2860
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P2860
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh-hant
name
Parkin directly modulates 26S proteasome activity.
@en
Parkin directly modulates 26S proteasome activity.
@nl
type
label
Parkin directly modulates 26S proteasome activity.
@en
Parkin directly modulates 26S proteasome activity.
@nl
prefLabel
Parkin directly modulates 26S proteasome activity.
@en
Parkin directly modulates 26S proteasome activity.
@nl
P2093
P1476
Parkin directly modulates 26S proteasome activity
@en
P2093
Christine Stichel-Gunkel
Hermann Lübbert
Hyun Jung Lee
Hyun-Soo Cho
Kwang Chul Chung
P304
11805-11814
P356
10.1523/JNEUROSCI.2862-09.2010
P407
P577
2010-09-01T00:00:00Z