An integrated chemical biology approach identifies specific vulnerability of Ewing's sarcoma to combined inhibition of Aurora kinases A and B.

An integrated chemical biology approach identifies specific vulnerability of Ewing's sarcoma to combined inhibition of Aurora kinases A and B.

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http://www.wikidata.org/entity/Q53232091
Potential approaches to the treatment of Ewing's sarcomaDevelopment of a preclinical orthotopic xenograft model of ewing sarcoma and other human malignant bone disease using advanced in vivo imagingTKI rotation-induced persistent deep molecular response in multi-resistant blast crisis of Ph+ CMLNew therapeutic targets in soft tissue sarcoma.Integrating phenotypic small-molecule profiling and human genetics: the next phase in drug discovery.Targeted therapies for advanced Ewing sarcoma family of tumors.Sarcoma Cell Line Screen of Oncology Drugs and Investigational Agents Identifies Patterns Associated with Gene and microRNA ExpressionA Class of Diacylglycerol Acyltransferase 1 Inhibitors Identified by a Combination of Phenotypic High-throughput Screening, Genomics, and GeneticsMolecular profiling of childhood cancer: Biomarkers and novel therapiesTargeting protein kinases to reverse multidrug resistance in sarcoma.Systems biology analysis of protein-drug interactions.Suppression of FOXO1 is responsible for a growth regulatory repressive transcriptional sub-signature of EWS-FLI1 in Ewing sarcoma.Building and exploring an integrated human kinase network: global organization and medical entry points.CINSARC: a new look into an old concept gives hope for new treatments for synovial sarcomas.Dual Targeting of WEE1 and PLK1 by AZD1775 Elicits Single Agent Cellular Anticancer Activity.Lapatinib potentiates cytotoxicity of  YM155 in neuroblastoma via inhibition of the ABCB1 efflux transporterPast, present, and future of Bcr-Abl inhibitors: from chemical development to clinical efficacy.
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An integrated chemical biology approach identifies specific vulnerability of Ewing's sarcoma to combined inhibition of Aurora kinases A and B.

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http://www.wikidata.org/entity/Q53232091
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2011 nî lūn-bûn
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2011年の論文
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年學術文章
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2011年學術文章
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name
An integrated chemical biology ...... ion of Aurora kinases A and B.
@en
An integrated chemical biology ...... ion of Aurora kinases A and B.
@nl
type
label
An integrated chemical biology ...... ion of Aurora kinases A and B.
@en
An integrated chemical biology ...... ion of Aurora kinases A and B.
@nl
prefLabel
An integrated chemical biology ...... ion of Aurora kinases A and B.
@en
An integrated chemical biology ...... ion of Aurora kinases A and B.
@nl
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An integrated chemical biology ...... tion of Aurora kinases A and B
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P2093
P304
P31
P356
10.1158/1535-7163.MCT-11-0100
P433
P478
P50
P577
P698