c-MYC overexpression with loss of Ink4a/Arf transforms bone marrow stromal cells into osteosarcoma accompanied by loss of adipogenesis.
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Osteosarcoma: Cells-of-Origin, Cancer Stem Cells, and Targeted TherapiesPresent Advances and Future Perspectives of Molecular Targeted Therapy for OsteosarcomaOsteosarcoma Genetics and Epigenetics: Emerging Biology and Candidate TherapiesUnderstanding the Biology of Bone Sarcoma from Early Initiating Events through Late Events in Metastasis and Disease ProgressionAdipocytes as a vehicle for ex vivo gene therapy: Novel replacement therapy for diabetes and other metabolic diseasesOsteosarcomagenesis: modeling cancer initiation in the mouse.Digital expression profiling identifies RUNX2, CDC5L, MDM2, RECQL4, and CDK4 as potential predictive biomarkers for neo-adjuvant chemotherapy response in paediatric osteosarcoma.Histone 3.3 hotspot mutations in conventional osteosarcomas: a comprehensive clinical and molecular characterization of six H3F3A mutated cases.Generation of Osteosarcomas from a Combination of Rb Silencing and c-Myc Overexpression in Human Mesenchymal Stem CellsThe tumor-suppressive microRNA-135b targets c-myc in osteoscarcoma.Notch activation as a driver of osteogenic sarcoma.Perturbation of 14q32 miRNAs-cMYC gene network in osteosarcoma.Up-regulation of Imp3 confers in vivo tumorigenicity on murine osteosarcoma cells.Mimicking p14ARF phosphorylation influences its ability to restrain cell proliferation.The molecular pathogenesis of osteosarcoma: a reviewMesenchymal stem cell transformation and sarcoma genesis.Defective osteogenic differentiation in the development of osteosarcoma.Isolation of side population cells from endometrial cancer cells using a violet laser diode.MDM2-mediated degradation of p14ARF: a novel mechanism to control ARF levels in cancer cells.BET inhibitors induce apoptosis through a MYC independent mechanism and synergise with CDK inhibitors to kill osteosarcoma cellsInk4a and Arf are crucial factors in the determination of the cell of origin and the therapeutic sensitivity of Myc-induced mouse lymphoid tumor.Chicken chorioallantoic membrane as a reliable model to evaluate osteosarcoma-an experimental approach using SaOS2 cell line.Synergistic antiproliferative effect of imatinib and adriamycin in platelet-derived growth factor receptor-expressing osteosarcoma cells.Dynamic epigenetic regulation of glioblastoma tumorigenicity through LSD1 modulation of MYC expression.Regulation of osteosarcoma cell lung metastasis by the c-Fos/AP-1 target FGFR1.Genetically engineered mouse models and human osteosarcoma.The role of mesenchymal stem/progenitor cells in sarcoma: update and dispute.Overexpression of KH-type splicing regulatory protein regulates proliferation, migration, and implantation ability of osteosarcoma.Mesenchymal Tumors Can Derive from Ng2/Cspg4-Expressing Pericytes with β-Catenin Modulating the Neoplastic Phenotype.Highly expressed ribosomal protein L34 indicates poor prognosis in osteosarcoma and its knockdown suppresses osteosarcoma proliferation probably through translational controlInk4a/Arf(-/-) and HRAS(G12V) transform mouse mammary cells into triple-negative breast cancer containing tumorigenic CD49f(-) quiescent cells.Modeling sarcomagenesis using multipotent mesenchymal stem cells.Complexity of cancer stem cells.Stem cell-based tissue engineering approaches for musculoskeletal regeneration.Senescence bypass in mesenchymal stem cells: a potential pathogenesis and implications of pro-senescence therapy in sarcomas.Proteomics of osteosarcoma.Regulation of MKL1 via actin cytoskeleton dynamics drives adipocyte differentiation.Pivotal regulatory network and genes in osteosarcomaColorectal Cancer Stem Cells Acquire Chemoresistance Through the Upregulation of F-Box/WD Repeat-Containing Protein 7 and the Consequent Degradation of c-Myc.Anoikis-resistant subpopulations of human osteosarcoma display significant chemoresistance and are sensitive to targeted epigenetic therapies predicted by expression profiling
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P2860
c-MYC overexpression with loss of Ink4a/Arf transforms bone marrow stromal cells into osteosarcoma accompanied by loss of adipogenesis.
description
2010 nî lūn-bûn
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2010年の論文
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
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2010年學術文章
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name
c-MYC overexpression with loss ...... anied by loss of adipogenesis.
@en
c-MYC overexpression with loss ...... anied by loss of adipogenesis.
@nl
type
label
c-MYC overexpression with loss ...... anied by loss of adipogenesis.
@en
c-MYC overexpression with loss ...... anied by loss of adipogenesis.
@nl
prefLabel
c-MYC overexpression with loss ...... anied by loss of adipogenesis.
@en
c-MYC overexpression with loss ...... anied by loss of adipogenesis.
@nl
P2093
P2860
P356
P1433
P1476
c-MYC overexpression with loss ...... anied by loss of adipogenesis.
@en
P2093
E Kobayashi
E Sugihara
H Ichikawa
R Nakayama
S Kuninaka
P2860
P2888
P304
P356
10.1038/ONC.2010.312
P407
P577
2010-08-02T00:00:00Z
P5875
P6179
1005238520