Random point mutations with major effects on protein-coding genes are the driving force behind premature aging in mtDNA mutator mice.
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Mitochondrial DNA replication and disease: insights from DNA polymerase γ mutationsChanges in Regenerative Capacity through LifespanModelling age-related metabolic disorders in the mouseEndogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic StressMitochondria in the Aging Muscles of Flies and Mice: New Perspectives for Old CharactersThe hallmarks of agingCancer and age related colonic crypt deficiencies in cytochrome c oxidase IMitochondria and oxidative stress in heart agingMitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator miceEndurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator miceAddressing RNA integrity to determine the impact of mitochondrial DNA mutations on brain mitochondrial function with age.The mtDNA mutator mouse: Dissecting mitochondrial involvement in aging.Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer's disease.Inactivation of Pif1 helicase causes a mitochondrial myopathy in miceChronic ethanol consumption increases myocardial mitochondrial DNA mutations: a potential contribution by mitochondrial topoisomerasesMitochondrial genome maintenance in health and disease.mip1 containing mutations associated with mitochondrial disease causes mutagenesis and depletion of mtDNA in Saccharomyces cerevisiaeUltra-deep sequencing of mouse mitochondrial DNA: mutational patterns and their origins.Mitochondrial DNA repair and association with aging--an updateMitochondrial DNA alterations and reduced mitochondrial function in agingRole of somatic mutations in vascular disease formation.Re-engineering the mitochondrial genomes in mammalian cellsTherapeutic prospects for mitochondrial disease.High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratioDNA damage and base excision repair in mitochondria and their role in aging.Mitochondrial DNA mutations in mutator mice confer respiration defects and B-cell lymphoma development.Heterozygous Polg mutation causes motor dysfunction due to mtDNA deletions.Sensitivity to low-dose/low-LET ionizing radiation in mammalian cells harboring mutations in succinate dehydrogenase subunit C is governed by mitochondria-derived reactive oxygen speciesDysregulation of mitochondrial quality control processes contribute to sarcopenia in a mouse model of premature aging.Metabolism, genomics, and DNA repair in the mouse aging liver.Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damageMitochondria DNA mutations cause sex-dependent development of hypertension and alterations in cardiovascular functionMitochondrial DNA mutations in disease and agingPost-translational decrease in respiratory chain proteins in the Polg mutator mouse brain.The mtDNA mutation spectrum of the progeroid Polg mutator mouse includes abundant control region multimersThe pleiotropic effect of physical exercise on mitochondrial dynamics in aging skeletal muscle.Mitochondrial Diseases Part II: Mouse models of OXPHOS deficiencies caused by defects in regulatory factors and other components required for mitochondrial function.Mitochondrial oxidative stress in aortic stiffening with age: the role of smooth muscle cell function.TP53 codon 72 polymorphism affects accumulation of mtDNA damage in human cells.Visualization of mitochondrial respiratory function using cytochrome c oxidase/succinate dehydrogenase (COX/SDH) double-labeling histochemistry.
P2860
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P2860
Random point mutations with major effects on protein-coding genes are the driving force behind premature aging in mtDNA mutator mice.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
Random point mutations with ma ...... e aging in mtDNA mutator mice.
@en
Random point mutations with ma ...... e aging in mtDNA mutator mice.
@nl
type
label
Random point mutations with ma ...... e aging in mtDNA mutator mice.
@en
Random point mutations with ma ...... e aging in mtDNA mutator mice.
@nl
prefLabel
Random point mutations with ma ...... e aging in mtDNA mutator mice.
@en
Random point mutations with ma ...... e aging in mtDNA mutator mice.
@nl
P2093
P50
P1433
P1476
Random point mutations with ma ...... e aging in mtDNA mutator mice.
@en
P2093
Aleksandra Trifunovic
Barbara Cannon
Daniel Edgar
Leo Nijtmans
Maria Antonietta Calvaruso
Yolanda Camara
P304
P356
10.1016/J.CMET.2009.06.010
P577
2009-08-01T00:00:00Z