Insulin-like growth factor-I receptor - a potential therapeutic target in medulloblastomas.
about
Inhibition of ERβ induces resistance to cisplatin by enhancing Rad51-mediated DNA repair in human medulloblastoma cell linesIGF-IR-dependent expression of Survivin is required for T-antigen-mediated protection from apoptosis and proliferation of neural progenitors.Targeting human medulloblastoma: oncolytic virotherapy with myxoma virus is enhanced by rapamycin.IGF-IR in neuroprotection and brain tumors.Nuclear IRS-1 and cancerYB-1 is elevated in medulloblastoma and drives proliferation in Sonic hedgehog-dependent cerebellar granule neuron progenitor cells and medulloblastoma cells.Activation of PPARalpha inhibits IGF-I-mediated growth and survival responses in medulloblastoma cell lines.Estrogen receptor beta-mediated nuclear interaction between IRS-1 and Rad51 inhibits homologous recombination directed DNA repair in medulloblastomaRole of the insulin-like growth factor I/insulin receptor substrate 1 axis in Rad51 trafficking and DNA repair by homologous recombination.Insulin receptor substrate 1 is an effector of sonic hedgehog mitogenic signaling in cerebellar neural precursors.Inhibition of IGF-I receptor in anchorage-independence attenuates GSK-3beta constitutive phosphorylation and compromises growth and survival of medulloblastoma cell lines.
P2860
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P2860
Insulin-like growth factor-I receptor - a potential therapeutic target in medulloblastomas.
description
2002 nî lūn-bûn
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2002年の論文
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年学术文章
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name
Insulin-like growth factor-I r ...... ic target in medulloblastomas.
@en
Insulin-like growth factor-I r ...... ic target in medulloblastomas.
@nl
type
label
Insulin-like growth factor-I r ...... ic target in medulloblastomas.
@en
Insulin-like growth factor-I r ...... ic target in medulloblastomas.
@nl
prefLabel
Insulin-like growth factor-I r ...... ic target in medulloblastomas.
@en
Insulin-like growth factor-I r ...... ic target in medulloblastomas.
@nl
P2860
P356
P1476
Insulin-like growth factor-I r ...... ic target in medulloblastomas.
@en
P2093
Krzysztof Reiss
P2860
P304
P356
10.1517/14728222.6.5.539
P407
P577
2002-10-01T00:00:00Z