Modulation of p53 protein conformation and DNA-binding activity by intracellular chelation of zinc.
about
Zinc-finger domains of the transcriptional repressor KLF15 bind multiple sites in rhodopsin and IRBP promoters including the CRS-1 and G-rich repressor elementsCadmium induces conformational modifications of wild-type p53 and suppresses p53 response to DNA damage in cultured cellsZinc and zinc transporter regulation in pancreatic islets and the potential role of zinc in islet transplantationp53/T-antigen complex disruption in T-antigen transformed NIH3T3 fibroblasts exposed to oxidative stress: correlation with the appearance of a Fas/APO-1/CD95 dependent, caspase independent, necrotic pathway.Stability of the core domain of p53: insights from computer simulations.Zinc and human health: an update.Unfolded p53 in the pathogenesis of Alzheimer's disease: is HIPK2 the link?MI-219-zinc combination: a new paradigm in MDM2 inhibitor-based therapyCytochemical techniques for zinc and heavy metals localization in nerve cells.Zinc: a promising agent in dietary chemoprevention of cancer.Mitochondrial dysfunction impairs tumor suppressor p53 expression/function.p53 and p73 display common and distinct requirements for sequence specific binding to DNAThe beneficial effect of Zinc(II) on low-dose chemotherapeutic sensitivity involves p53 activation in wild-type p53-carrying colorectal cancer cellsBiodegradable Metals for Cardiovascular Stents: from Clinical Concerns to Recent Zn-Alloys.Evaluation of zinc (II) chelators for inhibiting p53-mediated apoptosis.Enhancement of cellular antioxidant-defence preserves diastolic dysfunction via regulation of both diastolic Zn2+ and Ca2+ and prevention of RyR2-leak in hyperglycemic cardiomyocytes.A common variant within the HNF1B gene is associated with overall survival of multiple myeloma patients: results from the IMMEnSE consortium and meta-analysis.Redox modulation of p53: mechanisms and functional significance.Mutant p53 in cancer: new functions and therapeutic opportunities.DNA Structure and Polymerase Fidelity: A New Role for A-DNA.Effect of transition metals on binding of p53 protein to supercoiled DNA and to consensus sequence in DNA fragments.Improved cytotoxicity of pyridyl-substituted thiosemicarbazones against MCF-7 when used as metal ionophores.Antioxidant effects of zinc supplementation in Tunisians with type 2 diabetes mellitus.Phenotype-dependent apoptosis signalling in mesothelioma cells after selenite exposure.Zinc status affects p53, gadd45, and c-fos expression and caspase-3 activity in human bronchial epithelial cells.The cytoprotective aminothiol WR1065 activates p21waf-1 and down regulates cell cycle progression through a p53-dependent pathway.DNA damage-induced [Zn(2+)](i) transients: correlation with cell cycle arrest and apoptosis in lymphoma cells.p53 protein and p21 mRNA levels and caspase-3 activity are altered by zinc status in aortic endothelial cells.Evidence that wild-type p53 in neuroblastoma cells is in a conformation refractory to integration into the transcriptional complex.The substitutions G245C and G245D in the Zn(2+)-binding pocket of the p53 protein result in differences of conformational flexibility of the DNA-binding domain.Therapeutic targeting of p53: all mutants are equal, but some mutants are more equal than others.The Crystal Structure of the R280K Mutant of Human p53 Explains the Loss of DNA Binding.Copper-Binding Small Molecule Induces Oxidative Stress and Cell-Cycle Arrest in Glioblastoma-Patient-Derived Cells.
P2860
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P2860
Modulation of p53 protein conformation and DNA-binding activity by intracellular chelation of zinc.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh-hant
name
Modulation of p53 protein conf ...... tracellular chelation of zinc.
@en
Modulation of p53 protein conf ...... tracellular chelation of zinc.
@nl
type
label
Modulation of p53 protein conf ...... tracellular chelation of zinc.
@en
Modulation of p53 protein conf ...... tracellular chelation of zinc.
@nl
prefLabel
Modulation of p53 protein conf ...... tracellular chelation of zinc.
@en
Modulation of p53 protein conf ...... tracellular chelation of zinc.
@nl
P2860
P1476
Modulation of p53 protein conf ...... ntracellular chelation of zinc
@en
P2093
G W Verhaegh
M J Richard
P2860
P304
P356
10.1002/(SICI)1098-2744(199803)21:3<205::AID-MC8>3.0.CO;2-K
P577
1998-03-01T00:00:00Z