about
Predicting cell types and genetic variations contributing to disease by combining GWAS and epigenetic dataDNA-methylome analysis of mouse intestinal adenoma identifies a tumour-specific signature that is partly conserved in human colon cancerSimultaneous sequencing of oxidized methylcytosines produced by TET/JBP dioxygenases in Coprinopsis cinerea.MEDIPS: genome-wide differential coverage analysis of sequencing data derived from DNA enrichment experiments.Combinatorial binding in human and mouse embryonic stem cells identifies conserved enhancers active in early embryonic development.Quantitative Comparison of Large-Scale DNA Enrichment Sequencing Data.In silico identification of a core regulatory network of OCT4 in human embryonic stem cells using an integrated approach.QSEA-modelling of genome-wide DNA methylation from sequencing enrichment experiments.A data integration approach to mapping OCT4 gene regulatory networks operative in embryonic stem cells and embryonal carcinoma cells.Epigenomic analysis of primary human T cells reveals enhancers associated with TH2 memory cell differentiation and asthma susceptibilityComputational analysis of genome-wide DNA methylation during the differentiation of human embryonic stem cells along the endodermal lineageSimultaneous deletion of the methylcytosine oxidases Tet1 and Tet3 increases transcriptome variability in early embryogenesisAcute loss of TET function results in aggressive myeloid cancer in mice.A probabilistic generative model for quantification of DNA modifications enables analysis of demethylation pathways.Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX.Innate-like functions of natural killer T cell subsets result from highly divergent gene programs17q21 asthma-risk variants switch CTCF binding and regulate IL-2 production by T cells.Active medulloblastoma enhancers reveal subgroup-specific cellular origins.Tet proteins influence the balance between neuroectodermal and mesodermal fate choice by inhibiting Wnt signaling.Distinct roles of the methylcytosine oxidases Tet1 and Tet2 in mouse embryonic stem cells.Polymorphous low-grade neuroepithelial tumor of the young (PLNTY): an epileptogenic neoplasm with oligodendroglioma-like components, aberrant CD34 expression, and genetic alterations involving the MAP kinase pathway.Immunohistochemical analysis of H3K27me3 demonstrates global reduction in group-A childhood posterior fossa ependymoma and is a powerful predictor of outcome.DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis.Telomerase activation in posterior fossa group A ependymomas is associated with dismal prognosis and chromosome 1q gain.TET proteins regulate the lineage specification and TCR-mediated expansion of iNKT cells.Molecular characterization of cultured adult human liver progenitor cells.Dynamic Changes in Chromatin Accessibility Occur in CD8+ T Cells Responding to Viral Infection.The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine.Large conserved domains of low DNA methylation maintained by Dnmt3a.EPIG-04THE CHROMATIN LANDSCAPE OF MEDULLOBLASTOMA.Epithelioid glioblastomas stratify into established diagnostic subsets upon integrated molecular analysis.PNR-12GENOME-WIDE PROFILING OF EMBRYONAL TUMORS WITH MULTILAYERED ROSETTES (ETMR).EPN-34EPIGENOMIC ANALYSIS OF EPENDYMAL TUMORS IDENTIFIES SUBGROUP SPECIFIC ENHANCERS CONTROLLING DISTINCT REGULATORY CIRCUITRIES.TB-17A COMPREHENSIVE PAN-CANCER ANALYSIS OF CHILDHOOD MALIGNANCIES.The whole-genome landscape of medulloblastoma subtypes.Genetic confirmation that ependymoma can arise as part of multiple endocrine neoplasia type 1 (MEN1) syndrome.A mouse model for embryonal tumors with multilayered rosettes uncovers the therapeutic potential of Sonic-hedgehog inhibitors.Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling.Evidence of H3 K27M mutations in posterior fossa ependymomas.Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes.
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description
hulumtues
@sq
researcher
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ricercatore
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wetenschapper
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հետազոտող
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name
Lukas Chavez
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Lukas Chavez
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Lukas Chavez
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Lukas Chavez
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Lukas Chavez
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Lukas Chavez
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Lukas Chavez
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Lukas Chavez
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Lukas Chavez
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Lukas Chavez
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Lukas Chavez
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Lukas Chavez
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Lukas Chavez
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Lukas Chavez
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Lukas Chavez
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Lukas Chavez
@es
Lukas Chavez
@nl
Lukas Chavez
@sl
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P106
P21
P214
891154387134030970003
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1172311382
P31
P496
0000-0002-8718-8848
P735
P7859
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