about
Hypoxia induces PDK4 gene expression through induction of the orphan nuclear receptor ERRγPrivileged structures: efficient chemical "navigators" toward unexplored biologically relevant chemical spacesDiversity-oriented synthetic strategy for developing a chemical modulator of protein-protein interactionEfficient discovery of selective small molecule agonists of estrogen-related receptor gamma using combinatorial approach.Solid-phase parallel synthesis of natural product-like diaza-bridged heterocycles through Pictet-Spengler intramolecular cyclization.Concise and diversity-oriented synthesis of novel scaffolds embedded with privileged benzopyran motif.Practical solid-phase parallel synthesis of Delta(5)-2-oxopiperazines via N-acyliminium ion cyclization.Diversity-oriented synthesis of privileged benzopyranyl heterocycles from s-cis-enones.Construction of a polyheterocyclic benzopyran library with diverse core skeletons through diversity-oriented synthesis pathway.Heteroaromatic Moieties in the Sphingosine Backbone of α-Galactosylceramides for Noncovalent Interactions with CD1dPharmacophore-based strategy for the development of general and specific scFv biosensors for abused antibiotics.β-Turn mimetic-based stabilizers of protein-protein interactions for the study of the non-canonical roles of leucyl-tRNA synthetase.Emission wavelength prediction of a full-color-tunable fluorescent core skeleton, 9-aryl-1,2-dihydropyrrolo[3,4-b]indolizin-3-one.Solid-phase parallel synthesis of a tetrahydroindazolone library containing three unique core skeletons.Ethanol and reactive species increase basal sequence heterogeneity of hepatitis C virus and produce variants with reduced susceptibility to antivirals.A novel non-agonist peroxisome proliferator-activated receptor γ (PPARγ) ligand UHC1 blocks PPARγ phosphorylation by cyclin-dependent kinase 5 (CDK5) and improves insulin sensitivityRational perturbation of the fluorescence quantum yield in emission-tunable and predictable fluorophores (Seoul-Fluors) by a facile synthetic method involving C-H activation.Privileged substructure-based diversity-oriented synthesis pathway for diverse pyrimidine-embedded polyheterocycles.Synthesis and library construction of privileged tetra-substituted Δ5-2-oxopiperazine as β-turn structure mimetics.Anti-inflammatory effects of α-galactosylceramide analogs in activated microglia: involvement of the p38 MAPK signaling pathway.Discovery of carbohybrid-based 2-aminopyrimidine analogues as a new class of rapid-acting antimalarial agents using image-based cytological profiling assay.A high-content screening platform with fluorescent chemical probes for the discovery of first-in-class therapeutics.Orphan nuclear receptor estrogen-related receptor γ (ERRγ) is key regulator of hepatic gluconeogenesis.Synthesis of 3,5-Disubstituted Isoxazoles Containing Privileged Substructures with a Diverse Display of Polar Surface Area.Inverse agonist of nuclear receptor ERRγ mediates antidiabetic effect through inhibition of hepatic gluconeogenesis.Lentiviral vector-mediated shRNA against AIMP2-DX2 suppresses lung cancer cell growth through blocking glucose uptake.Anti-obesity agents: a focused review on the structural classification of therapeutic entities.Chemistry as a prism: a review of light-emitting materials having tunable emission wavelengths.Label-free target identification using in-gel fluorescence difference via thermal stability shift.The O‑glycosylation mutant osteopontin alters lung cancer cell growth and migration in vitro and in vivo.Synthesis and biological evaluation of pyrimidine-based dual inhibitors of human epidermal growth factor receptor 1 (HER-1) and HER-2 tyrosine kinases.Treatment of Sepsis Pathogenesis with High Mobility Group Box Protein 1-Regulating Anti-inflammatory Agents.A nonthiazolidinedione peroxisome proliferator-activated receptor α/γ dual agonist CG301360 alleviates insulin resistance and lipid dysregulation in db/db mice.Estrogen-related receptor gamma induces cardiac hypertrophy by activating GATA4.Total synthesis of eryvarin H and its derivatives and their biological activity as ERRγ inverse agonist.Facile and efficient synthesis of carbohybrids as stereodivergent druglike small molecules.Focus on chemical biology in Asia.Monochromophoric Design Strategy for Tetrazine-Based Colorful Bioorthogonal Probes with a Single Fluorescent Core Skeleton.Readily Accessible and Predictable Naphthalene-Based Two-Photon Fluorophore with Full Visible-Color Coverage.Structural Basis for the Enhanced Anti-Diabetic Efficacy of Lobeglitazone on PPARγ.
P50
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P50
description
onderzoeker
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researcher
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հետազոտող
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name
Seung Bum Park
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Seung Bum Park
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Seung Bum Park
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Seung Bum Park
@nl
Seung Bum Park
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label
Seung Bum Park
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Seung Bum Park
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Seung Bum Park
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Seung Bum Park
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Seung Bum Park
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prefLabel
Seung Bum Park
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Seung Bum Park
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Seung Bum Park
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Seung Bum Park
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Seung Bum Park
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P106
P1153
35280777800
P31
P496
0000-0003-1753-1433