Mutational hotspot in the p53 gene in human hepatocellular carcinomas.
about
The aflatoxin B(1) formamidopyrimidine adduct plays a major role in causing the types of mutations observed in human hepatocellular carcinomaAflatoxin B1 induces the transversion of G-->T in codon 249 of the p53 tumor suppressor gene in human hepatocytesSusceptibility to hepatocellular carcinoma is associated with genetic variation in the enzymatic detoxification of aflatoxin B1MycotoxinsAcrolein is a major cigarette-related lung cancer agent: Preferential binding at p53 mutational hotspots and inhibition of DNA repairEstablishment of a doxycycline-regulated cell line with inducible, doubly-stable expression of the wild-type p53 gene from p53-deleted hepatocellular carcinoma cellsNew advances in hepatocellular carcinomaPrecision Medicine and Non-Colorectal Cancer Liver Metastases: Fiction or Reality?Hepatocellular carcinoma: From clinical practice to evidence-based treatment protocolsRisk factors for hepatocellular carcinoma in IndiaHepatitis B virus, HBx mutants and their role in hepatocellular carcinomaAberrant Promoter Methylation Profiles of Tumor Suppressor Genes in Hepatocellular CarcinomaHarnessing the RNA interference pathway to advance treatment and prevention of hepatocellular carcinomaStructural Perturbations Induced by the α-Anomer of the Aflatoxin B 1 Formamidopyrimidine Adduct in Duplex and Single-Strand DNABypass of Aflatoxin B 1 Adducts by the Sulfolobus solfataricus DNA Polymerase IVDNA strand-specific repair of (+-)-3 alpha,4 beta-dihydroxy-1 alpha,2 alpha-epoxy-1,2,3,4-tetrahydrobenzo[c]phenanthrene adducts in the hamster dihydrofolate reductase geneDeterminants of specificity for aflatoxin B1-8,9-epoxide in alpha-class glutathione S-transferasesAlterations in the K-ras and p53 genes in rat lung tumorsThe "two-faced" effects of reactive oxygen species and the lipid peroxidation product 4-hydroxynonenal in the hallmarks of cancerIntegration of tumour and viral genomic characterizations in HBV-related hepatocellular carcinomasThe global epidemiology of hepatocellular carcinoma: present and futureAdvances in chemical carcinogenesis: a historical review and prospectiveBase changes in tumour DNA have the power to reveal the causes and evolution of cancer.Mutational spectra of aflatoxin B1 in vivo establish biomarkers of exposure for human hepatocellular carcinoma.Evolutionary conservation and somatic mutation hotspot maps of p53: correlation with p53 protein structural and functional features.Tumor-suppressor genes: cardinal factors in inherited predisposition to human cancersPotential role of p53 mutation in chemical hepatocarcinogenesis of rats.A population-based study to investigate host genetic factors associated with hepatitis B infection and pathogenesis in the Chinese population.249 TP53 mutation has high prevalence and is correlated with larger and poorly differentiated HCC in Brazilian patients.Hepatitis C-associated hepatocellular carcinomas in non-cirrhotic livers.Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma.Environmental factors as regulators and effectors of multistep carcinogenesis.Involvement of DNA damage response pathways in hepatocellular carcinoma.Molecular epidemiology of human cancer risk: gene-environment interactions and p53 mutation spectrum in human lung cancer.Field cancerization, clonality, and epithelial stem cells: the spread of mutated clones in epithelial sheets.Chemical Biology of N5-Substituted Formamidopyrimidine DNA Adducts.Histone methyltransferase SETDB1 regulates liver cancer cell growth through methylation of p53Formation of 8-nitroguanine, a nitrative DNA lesion, in inflammation-related carcinogenesis and its significance.Unexpected aflatoxin exposure in a woman in northern Italy: a case report.TP53 mutations in human cancers: origins, consequences, and clinical use
P2860
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P2860
Mutational hotspot in the p53 gene in human hepatocellular carcinomas.
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年学术文章
@wuu
1991年学术文章
@zh
1991年学术文章
@zh-cn
1991年学术文章
@zh-hans
1991年学术文章
@zh-my
1991年学术文章
@zh-sg
1991年學術文章
@yue
1991年學術文章
@zh-hant
name
Mutational hotspot in the p53 gene in human hepatocellular carcinomas.
@en
Mutational hotspot in the p53 gene in human hepatocellular carcinomas.
@nl
type
label
Mutational hotspot in the p53 gene in human hepatocellular carcinomas.
@en
Mutational hotspot in the p53 gene in human hepatocellular carcinomas.
@nl
prefLabel
Mutational hotspot in the p53 gene in human hepatocellular carcinomas.
@en
Mutational hotspot in the p53 gene in human hepatocellular carcinomas.
@nl
P2093
P356
P1433
P1476
Mutational hotspot in the p53 gene in human hepatocellular carcinomas.
@en
P2093
P2888
P304
P356
10.1038/350427A0
P407
P577
1991-04-01T00:00:00Z
P6179
1026041841