Design, synthesis, and pharmacological evaluation of highly potent and selective dipeptidyl peptidase-4 inhibitors.

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Design, synthesis, and pharmacological evaluation of highly potent and selective dipeptidyl peptidase-4 inhibitors.

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2015 nî lūn-bûn

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2015年の論文

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2015年学术文章

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2015年学术文章

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2015年学术文章

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2015年学术文章

@zh-my

2015年学术文章

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2015年學術文章

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2015年學術文章

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2015年學術文章

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Design, synthesis, and pharmac ...... ptidyl peptidase-4 inhibitors.

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Design, synthesis, and pharmac ...... ptidyl peptidase-4 inhibitors.

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Item

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Design, synthesis, and pharmac ...... ptidyl peptidase-4 inhibitors.

@en

Design, synthesis, and pharmac ...... ptidyl peptidase-4 inhibitors.

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Design, synthesis, and pharmac ...... ptidyl peptidase-4 inhibitors.

@en

Design, synthesis, and pharmac ...... ptidyl peptidase-4 inhibitors.

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P1476

Design, synthesis, and pharmac ...... ptidyl peptidase-4 inhibitors.

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P2093

Bo Li

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Heyao Wang

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Jianming Zhu

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Jingshan Shen

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Peng Sun

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Qiang Shao

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Qiang Zhang

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Tao Jiang

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Weiliang Zhu

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Xiangrui Jiang

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P2860

Discovery of alogliptin: a potent, selective, bioavailable, and efficacious inhibitor of dipeptidyl peptidase IV

8-(3-(R)-aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione (BI 1356), a highly potent, selective, long-acting, and orally bioavailable DPP-4 inhibitor for the treatment of type 2 diabetes

Design and synthesis of 4-(2,4,5-trifluorophenyl)butane-1,3-diamines as dipeptidyl peptidase IV inhibitors

Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum

Determinants of the effectiveness of glucagon-like peptide-1 in type 2 diabetes

Discovery and preclinical profile of Saxagliptin (BMS-477118): a highly potent, long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

A comparison of physiochemical property profiles of development and marketed oral drugs.

Development and characterization of 3-(benzylsulfonamido)benzamides as potent and selective SIRT2 inhibitors

Molecular properties that influence the oral bioavailability of drug candidates.

Novel class of benzoic acid ester derivatives as potent PDE4 inhibitors for inhaled administration in the treatment of respiratory diseases.

P304

399-407

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scholarly article

P356

10.1002/ARDP.201500082

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P433

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P478

348

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P577

2015-04-14T00:00:00Z

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P698

25871012

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