Cdc42 controls the polarity of the actin and microtubule cytoskeletons through two distinct signal transduction pathways.
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Asef2 functions as a Cdc42 exchange factor and is stimulated by the release of an autoinhibitory module from a concealed C-terminal activation elementPaxillin phosphorylation at Ser273 localizes a GIT1-PIX-PAK complex and regulates adhesion and protrusion dynamicsMutations in FGD4 encoding the Rho GDP/GTP exchange factor FRABIN cause autosomal recessive Charcot-Marie-Tooth type 4HCritical role of actin-associated proteins in smooth muscle contraction, cell proliferation, airway hyperresponsiveness and airway remodelingRho GTPases at the crossroad of signaling networks in mammals: impact of Rho-GTPases on microtubule organization and dynamicsRho GTPases in collective cell migrationSubcellular optogenetic activation of Cdc42 controls local and distal signaling to drive immune cell migration.CARMIL2 is a novel molecular connection between vimentin and actin essential for cell migration and invadopodia formationP-cadherin promotes collective cell migration via a Cdc42-mediated increase in mechanical forcesClostridium difficile toxin CDT induces formation of microtubule-based protrusions and increases adherence of bacteriaA Golgi-localized pool of the mitotic checkpoint component Mad1 controls integrin secretion and cell migration.Schwann cells induce cancer cell dispersion and invasion.The p38/MK2/Hsp25 pathway is required for BMP-2-induced cell migrationThe tumour-suppressor Scribble dictates cell polarity during directed epithelial migration: regulation of Rho GTPase recruitment to the leading edgeHEF1-aurora A interactions: points of dialog between the cell cycle and cell attachment signaling networksBiochemical and functional characterization of the interaction between liprin-α1 and GIT1: implications for the regulation of cell motilityHere come the septins: novel polymers that coordinate intracellular functions and organizationAPC nuclear membrane association and microtubule polarityLocalized activation of p21-activated kinase controls neuronal polarity and morphologyRandom versus directionally persistent cell migrationMyosin II directly binds and inhibits Dbl family guanine nucleotide exchange factors: a possible link to Rho family GTPases.Regulation of actin cytoskeleton dynamics by Arf-family GTPases.Paxillin-kinase-linker tyrosine phosphorylation regulates directional cell migration.Polarity reveals intrinsic cell chiralityaPKC controls microtubule organization to balance adherens junction symmetry and planar polarity during developmentThe tumor suppressor DAPK inhibits cell motility by blocking the integrin-mediated polarity pathway.Cdc42 controls spindle orientation to position the apical surface during epithelial morphogenesis.PAK1-mediated activation of ERK1/2 regulates lamellipodial dynamics.Pak3 inhibits local actin filament formation to regulate global cell polarity.Cyfip1 is a putative invasion suppressor in epithelial cancers.Dkk-1 inhibits intestinal epithelial cell migration by attenuating directional polarization of leading edge cellsThe small Rho GTPase Cdc42 regulates neutrophil polarity via CD11b integrin signalingCdc42 regulates neutrophil migration via crosstalk between WASp, CD11b, and microtubulesRegulation of neural progenitor cell motility by ceramide and potential implications for mouse brain developmentSpecific deletion of Cdc42 does not affect meiotic spindle organization/migration and homologous chromosome segregation but disrupts polarity establishment and cytokinesis in mouse oocytes.β-Pix directs collective migration of anterior visceral endoderm cells in the early mouse embryoGOLPH3 drives cell migration by promoting Golgi reorientation and directional trafficking to the leading edge.Computational cell model based on autonomous cell movement regulated by cell-cell signalling successfully recapitulates the "inside and outside" pattern of cell sorting.A modifier screen in the Drosophila eye reveals that aPKC interacts with Glued during central synapse formationCDC42 is required for epicardial and pro-epicardial development by mediating FGF receptor trafficking to the plasma membrane
P2860
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P2860
Cdc42 controls the polarity of the actin and microtubule cytoskeletons through two distinct signal transduction pathways.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh-hant
name
Cdc42 controls the polarity of ...... signal transduction pathways.
@en
Cdc42 controls the polarity of ...... signal transduction pathways.
@nl
type
label
Cdc42 controls the polarity of ...... signal transduction pathways.
@en
Cdc42 controls the polarity of ...... signal transduction pathways.
@nl
prefLabel
Cdc42 controls the polarity of ...... signal transduction pathways.
@en
Cdc42 controls the polarity of ...... signal transduction pathways.
@nl
P356
P1476
Cdc42 controls the polarity of ...... signal transduction pathways.
@en
P2093
P304
P356
10.1242/JCS.02385
P407
P577
2005-05-31T00:00:00Z