about
Telomeres in Cancer TherapyTelomere maintenance requires the RAD51D recombination/repair proteinMammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres.Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice.Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancerTelomeres and telomerase as therapeutic targets to prevent and treat age-related diseasesA GRFa2/Prop1/stem (GPS) cell niche in the pituitaryBRCA2 acts as a RAD51 loader to facilitate telomere replication and cappingThe hallmarks of agingTelomerase regulation and stem cell behaviourPOT1 mutations cause telomere dysfunction in chronic lymphocytic leukemiaThe role of telomeres and telomerase in stem cell agingTelomeres acquire embryonic stem cell characteristics in induced pluripotent stem cellsIncreased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes.Telomere lengthening early in developmentMammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sitesEffects of telomerase and telomere length on epidermal stem cell behaviorSox4 links tumor suppression to accelerated aging in mice by modulating stem cell activationA p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrityThe Ink4/Arf locus is a barrier for iPS cell reprogrammingPersonal omics profiling reveals dynamic molecular and medical phenotypesTelomere shortening and tumor formation by mouse cells lacking telomerase RNAMolecular Architecture of Full-length TRF1 Favors Its Interaction with DNATopoIIα prevents telomere fragility and formation of ultra thin DNA bridges during mitosis through TRF1-dependent binding to telomeresTelomeres and telomerase in Alzheimer's disease: epiphenomena or a new focus for therapeutic strategy?Single-cell telomere-length quantification couples telomere length to meristem activity and stem cell development in ArabidopsisA p53-dependent response limits epidermal stem cell functionality and organismal size in mice with short telomeres.Critically short telomeres and toxicity of chemotherapy in early breast cancerIrregular telomeres impair meiotic synapsis and recombination in mice.ATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase.TERRA transcripts are bound by a complex array of RNA-binding proteins.SIRT1 is necessary for proficient telomere elongation and genomic stability of induced pluripotent stem cells.Requirement of functional telomeres for metaphase chromosome alignments and integrity of meiotic spindles.Restoration of telomerase activity rescues chromosomal instability and premature aging in Terc-/- mice with short telomeres.p53 Modulates the Fate of Cardiac Progenitor Cells Ex Vivo and in the Diabetic Heart In Vivo.Mice with bad ends: mouse models for the study of telomeres and telomerase in cancer and aging.The absence of the dna-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang.Telomerase reverse transcriptase delays aging in cancer-resistant mice.Suv4-20h abrogation enhances telomere elongation during reprogramming and confers a higher tumorigenic potential to iPS cellsTelomere rejuvenation during nuclear reprogramming.
P50
Q21146989-D8E9103E-E66B-471F-A821-FFFE17DBFFE4Q24338140-A7202206-67B2-4617-8314-7229FEA5AE96Q24536297-94FA5FF0-F474-4304-A2A4-F7AEDB393F0FQ24537136-8BD0A428-6F00-4B46-83F4-6B9AAD97E863Q24615809-D8082355-DA85-42F3-8266-D62F0020B0B3Q26747735-B6B67C09-8BDD-4CEE-A172-E17679F4DD34Q27350395-5BD0E4EC-2B16-4A3F-A338-5A8B113C8B68Q28115349-3230936B-7497-4524-A8EF-F862E5418605Q28131641-8BA289CC-2F7D-4497-ADF0-EB39484C5176Q28235041-E59C599C-9992-4DF9-9F81-992CD588F8F4Q28287338-3E5049CD-AF0E-4675-8B74-4050049AD944Q28289389-30E00DA8-F0B9-4284-997A-294C13774A89Q28308249-ACF50240-2FDD-4F14-82F6-406AA3599CE5Q28366118-4BF11BA9-A34E-4C99-9E60-9F1538FB1E6BQ28512777-D9722379-A4D2-4D0F-8498-D0B46F10D158Q28585250-CAD7017B-6D64-4CC2-A43A-40AF00EA2619Q28592564-797BD0AA-BDEC-4941-B28B-710A42A442ACQ28830512-095C6F64-62F4-44C7-9EE6-67C584E009D6Q29614209-64168B1C-58A5-4ED9-9D03-46B2007B121CQ29614210-5A167FCA-FB28-499C-8432-977B06604345Q29614800-F45DDB53-689B-460D-B9E7-88DE90E5E5B7Q29615386-B7FB4293-6A5C-4FFB-B42C-F8B331999F32Q30392263-CD2C2718-6119-49FF-BF96-EE5A0F7F43ECQ30580233-9EC90F83-3DAC-482C-A43F-A2E1E00992CBQ33347411-C25F87E3-9AAE-4A9A-8720-9C5442CC1A45Q33360622-4934A5F4-0C19-4AE3-A713-E458B325FC87Q33419378-1F4875DC-2C73-422F-8104-5B77B665FE27Q33591567-B9DC804F-87A1-4907-9D4E-611D5EA43124Q33695241-3FCFB287-2301-4FE4-B235-10EFE3EECF80Q33717036-A26CE3E8-317C-4632-804D-64B10AEF9A0EQ33727847-5AC0A8D6-91B5-4724-ACF2-252D56F4D802Q33730161-35F1E77C-BF47-4CD0-8374-1E7E7E431D81Q33757640-F8CFA08E-9FF6-4768-B50A-E1858D8FC8DCQ33757674-1917B385-F4CC-403D-AB78-B177E5F3E000Q33809750-997FE095-81C5-4292-BE2E-1384F636E27FQ33937189-F616B94B-4F37-4723-A106-2C4F9125169BQ33968202-499D5C85-B9C6-4212-AB73-3ADA34180D38Q34014691-2FA5E4EF-B804-4949-91C0-623D67C3E99FQ34055695-22A0B84D-00FD-40C3-A315-3A7251343F84Q34100113-00812531-54EE-414B-840D-77E661B214B4
P50
description
hulumtuese
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Maria A Blasco
@ast
Maria A Blasco
@en
Maria A Blasco
@es
Maria A Blasco
@nl
Maria A Blasco
@sl
type
label
Maria A Blasco
@ast
Maria A Blasco
@en
Maria A Blasco
@es
Maria A Blasco
@nl
Maria A Blasco
@sl
altLabel
Maria A. Blasco
@en
prefLabel
Maria A Blasco
@ast
Maria A Blasco
@en
Maria A Blasco
@es
Maria A Blasco
@nl
Maria A Blasco
@sl
P1053
M-1694-2014
P106
P21
P31
P496
0000-0002-4211-233X