Furin-mediated cleavage of Pseudomonas exotoxin-derived chimeric toxins.
about
Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogensTGFα-PE38 enhances cytotoxic T-lymphocyte killing of breast cancer cells.Efficiency of immunotoxin cytotoxicity is modulated by the intracellular itinerary.Convergent potency of internalized gelonin immunotoxins across varied cell lines, antigens, and targeting moietiesWhole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicityA human papillomavirus (HPV) in vitro neutralization assay that recapitulates the in vitro process of infection provides a sensitive measure of HPV L2 infection-inhibiting antibodies.In vitro and in vivo antitumor effects of the recombinant immunotoxin IL6(T23)-PE38KDEL in multiple myelomaAnti-tumor effects of a recombinant anti-prostate specific membrane antigen immunotoxin against prostate cancer cells.A recombinant immunotoxin against the tumor-associated antigen mesothelin reengineered for high activity, low off-target toxicity, and reduced antigenicityThe insulin receptor negatively regulates the action of Pseudomonas toxin-based immunotoxins and native Pseudomonas toxin.Identification of a role for the trans-Golgi network in human papillomavirus 16 pseudovirus infection.Reoxygenation of hypoxic glioblastoma multiforme cells potentiates the killing effect of an interleukin-13-based cytotoxin.Heparan sulfate-independent cell binding and infection with furin-precleaved papillomavirus capsids.Furin Cleavage of L2 during Papillomavirus Infection: Minimal Dependence on CyclophilinsAntitumor effects of immunotoxins are enhanced by lowering HCK or treatment with SRC kinase inhibitors.Vibrio cholerae Cholix Toxin-Induced HepG2 Cell Death is Enhanced by Tumor Necrosis Factor-Alpha Through ROS and Intracellular Signal-Regulated Kinases.The furin inhibitor hexa-D-arginine blocks the activation of Pseudomonas aeruginosa exotoxin A in vivo.Selective and potent furin inhibitors protect cells from anthrax without significant toxicitySubstrate cleavage analysis of furin and related proprotein convertases. A comparative study.Recombinant Immunotoxin Therapy of Glioblastoma: Smart Design, Key Findings, and Specific Challenges.Molecular targeting of intracellular compartments specifically in cancer cells.Toward intracellular targeted delivery of cancer therapeutics: progress and clinical outlook for brain tumor therapy.Internalized Pseudomonas exotoxin A can exploit multiple pathways to reach the endoplasmic reticulum.Domain II of Pseudomonas Exotoxin Is Critical for Efficacy of Bolus Doses in a Xenograft Model of Acute Lymphoblastic Leukemia.
P2860
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P2860
Furin-mediated cleavage of Pseudomonas exotoxin-derived chimeric toxins.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh
1997年學術文章
@zh-hant
name
Furin-mediated cleavage of Pseudomonas exotoxin-derived chimeric toxins.
@en
Furin-mediated cleavage of Pseudomonas exotoxin-derived chimeric toxins.
@nl
type
label
Furin-mediated cleavage of Pseudomonas exotoxin-derived chimeric toxins.
@en
Furin-mediated cleavage of Pseudomonas exotoxin-derived chimeric toxins.
@nl
prefLabel
Furin-mediated cleavage of Pseudomonas exotoxin-derived chimeric toxins.
@en
Furin-mediated cleavage of Pseudomonas exotoxin-derived chimeric toxins.
@nl
P2093
P2860
P356
P1476
Furin-mediated cleavage of Pseudomonas exotoxin-derived chimeric toxins.
@en
P2093
FitzGerald D
Fryling CM
P2860
P304
31707-31711
P356
10.1074/JBC.272.50.31707
P407
P577
1997-12-01T00:00:00Z